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1. (WO2019028250) NANOSCALE METAL-ORGANIC LAYERS AND METAL-ORGANIC NANOPLATES FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF
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Pub. No.: WO/2019/028250 International Application No.: PCT/US2018/045005
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
A61N 5/06 (2006.01) ,A61K 31/282 (2006.01) ,C07D 487/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
N
ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5
Radiation therapy
06
using light
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
282
Platinum compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
22
in which the condensed system contains four or more hetero rings
Applicants:
THE UNIVERSITY OF CHICAGO [US/US]; 6030 South Ellis Edelstone 2S Chicago, IL 60637, US
Inventors:
LIN, Wenbin; US
NI, Kaiyuan; US
LAN, Guangxu; US
Agent:
TAYLOR, Arles, A., Jr.; US
Priority Data:
62/540,27502.08.2017US
62/623,82630.01.2018US
Title (EN) NANOSCALE METAL-ORGANIC LAYERS AND METAL-ORGANIC NANOPLATES FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF
(FR) COUCHES ORGANOMÉTALLIQUES NANOMÉTRIQUES ET NANOPLAQUES ORGANOMÉTALLIQUES POUR THÉRAPIE PHOTODYNAMIQUE INDUITE PAR RAYONS X, RADIOTHÉRAPIE, THÉRAPIE RODIODYNAMIQUE, CHIMIOTHÉRAPIE, IMMUNOTHÉRAPIE, ET TOUTE COMBINAISON DE CELLES-CI
Abstract:
(EN) Metal-organic layers (MOLs) and metal-organic nanoplates (MOPs) comprising photosensitizers are described. The MOLs and MOPs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation. Optionally, the photosensitizer or a derivative thereof can form a bridging ligand of the MOL or MOP. Also described are methods of using MOLs and MOPs in photodynamic therapy, X-ray induced photodynamic therapy (X-PDT), radiotherapy (RT), radiodynamic therapy, or in radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator.
(FR) L'invention concerne des couches organométalliques (MOL) et des nanoplaques organométalliques (MOP) comprenant des photosensibilisateurs. Les MOL et les MOP peuvent également comprendre des fractions capables d'absorber des rayons X ou une autre énergie d'irradiation ionisante et/ou de scintillation. Facultativement, le photosensibilisateur ou un dérivé de celui-ci peut former un ligand de pontage de la MOL ou de la MOP. L'invention concerne également des procédés d'utilisation des MOL et des MOP en thérapie photodynamique, en thérapie photodynamique induite par rayons X (X-PDT), en radiothérapie (RT), en thérapie radiodynamique, ou en radiothérapie-thérapie radiodynamique (RT-RDT), avec ou sans la co-administration d'un autre agent thérapeutique, tel qu'un agent chimiothérapeutique ou un immunomodulateur.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)