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1. (WO2019028228) PROCESSES FOR PREPARING PYRROLIDINE COMPOUNDS
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Pub. No.: WO/2019/028228 International Application No.: PCT/US2018/044963
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
C07D 207/06 (2006.01) ,C07D 207/263 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
06
with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18
having one double bond between ring members or between a ring member and a non-ring member
22
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24
Oxygen or sulfur atoms
26
2-Pyrrolidones
263
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
Applicants:
VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 50 Northern Avenue Boston, Massachusetts 02210, US
Inventors:
ANGELL, Paul T.; US
LEWANDOWSKI, Berenice; US
LITTLER, Benjamin J.; US
NUGENT, William A.; US
SMITH, David; US
STUDLEY, John; US
Agent:
MCDONELL, Leslie A.; US
MACALPINE, Jill K.; US
RODRIGO, Christina M.; US
Priority Data:
62/540,39502.08.2017US
Title (EN) PROCESSES FOR PREPARING PYRROLIDINE COMPOUNDS
(FR) PROCÉDÉS DE PRÉPARATION DE COMPOSÉS DE PYRROLIDINE
Abstract:
(EN) Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.
(FR) L'invention concerne des procédés de préparation de 5,5-diméthyl-3-méthylènepyrrolidin-2-one, (S)-3,5,5-triméthylpyrrolidine-2-one, (R)-3,5,5-triméthylpyrrolidine-2-one, (S)-2,4,4-triméthylpyrrolidine, et de (R)-2,4,4-triméthylpyrrolidine, ainsi que leurs formes de sels.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)