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1. (WO2019028171) DHODH INHIBITOR FOR USE IN TREATING HEMATOLOGIC CANCERS
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Pub. No.: WO/2019/028171 International Application No.: PCT/US2018/044862
Publication Date: 07.02.2019 International Filing Date: 01.08.2018
IPC:
A61K 31/437 (2006.01) ,A61P 35/02 (2006.01) ,C07D 471/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
PTC THERAPEUTICS, INC. [US/US]; 100 Corporate Court Middlesex Business Center South Plainfield, NJ 07080, US
Inventors:
CAO, Liangxian; US
WEETALL, Maria; US
Agent:
SCOLA, Daniel, A., Jr.; US
ABBRUZZESE, Salvatore, J.; US
WILKOVICH, Andrea, M.; US
SOPKO, John, S.; US
NEUNER, Robert; US
Priority Data:
62/540,05101.08.2017US
62/617,18013.01.2018US
Title (EN) DHODH INHIBITOR FOR USE IN TREATING HEMATOLOGIC CANCERS
(FR) INHIBITEUR DE DHODH POUR UTILISATION DANS LE TRAITEMENT DE CANCERS HÉMATOLOGIQUES
Abstract:
(EN) A method of use for Cpd 1 as an inhibitor of dihydroorotate dehydrogenase (DHODH) function in treating or ameliorating a hematological cancer in a subject in need thereof comprising, administering an effective amount of Cpd 1 to the subject, having structure (I); or a form or pharmaceutical composition thereof.
(FR) La présente invention concerne un procédé d'utilisation du Comp 1 en tant qu'inhibiteur de la fonction de la dihydroorotate déshydrogénase (DHODH) dans le traitement ou le soulagement d'un cancer hématologique chez un sujet le nécessitant, comprenant l'administration d'une quantité active du Comp 1 au sujet, répondant à la structure (I); ou une forme ou une composition pharmaceutique de celui-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)