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1. (WO2019028168) SOLID-PHASE SYNTHESIS OF PROTEIN-POLYMER CONJUGATES ON IMMOBILIZATION SUPPORTS
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Pub. No.: WO/2019/028168 International Application No.: PCT/US2018/044859
Publication Date: 07.02.2019 International Filing Date: 01.08.2018
IPC:
C07D 207/404 (2006.01) ,C07K 1/04 (2006.01) ,C07K 1/10 (2006.01) ,C07K 17/02 (2006.01) ,C07K 17/06 (2006.01) ,C08B 37/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30
having two double bonds between ring members or between ring members and non-ring members
34
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36
Oxygen or sulfur atoms
40
2,5-Pyrrolidine-diones
404
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
04
on carriers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
10
using coupling agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
02
Peptides being immobilised on, or in, an organic carrier
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
02
Peptides being immobilised on, or in, an organic carrier
06
attached to the carrier via a bridging agent
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
B
POLYSACCHARIDES; DERIVATIVES THEREOF
37
Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
12
Agar-agar; Derivatives thereof
Applicants:
MURATA, Hironobu [JP/US]; US
RUSSELL, Alan J. [US/US]; US
Inventors:
MURATA, Hironobu; US
RUSSELL, Alan J.; US
Agent:
KAYTOR, Elizabeth N.; US
ATTWELL, Gwilym J.; US
Priority Data:
62/605,10401.08.2017US
Title (EN) SOLID-PHASE SYNTHESIS OF PROTEIN-POLYMER CONJUGATES ON IMMOBILIZATION SUPPORTS
(FR) SYNTHÈSE EN PHASE SOLIDE DE CONJUGUÉS PROTÉINE-POLYMÈRE SUR DES SUPPORTS D'IMMOBILISATION
Abstract:
(EN) Materials and methods for generating protein-polymer conjugates on solid supports are provided herein. The methods can include, for example, reversibly immobilizing a protein on a solid support, modifying the protein by adding polymer subunits, and releasing the protein-polymer conjugate from the solid support.
(FR) L'invention concerne des matériaux et des procédés pour la génération de conjugués protéine-polymère sur des supports solides. Les procédés peuvent comprendre, par exemple, l'immobilisation réversible d'une protéine sur un support solide, la modification de la protéine par ajout de sous-unités polymères, et la libération du conjugué protéine-polymère à partir du support solide.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)