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1. (WO2019028104) NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
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Pub. No.: WO/2019/028104 International Application No.: PCT/US2018/044747
Publication Date: 07.02.2019 International Filing Date: 01.08.2018
IPC:
A61K 31/425 (2006.01) ,A61K 31/426 (2006.01) ,A61K 31/428 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
428
condensed with carbocyclic rings
Applicants:
ALPHALA CO., LTD.; No. 83-2, Sec. 2, Chengde Rd. Datong Dist. Taipei City, 103, TW
CHEN, Chung-Chin [US/US]; US (US)
Inventors:
CHUNG, Cheng-Ho; TW
TSENG, Shi-Liang; TW
CHEN, Yen-Fu; TW
LEE, Jian-Bin; TW
Agent:
URCIA, Benjamin Edward; US
MAR, Eugene; US
MOORE, Thomas J.; US
D'AMBROSIO, Felix J.; US
LEE, Thomas; US
Priority Data:
62/540,11402.08.2017US
Title (EN) NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
(FR) NOUVEAU COMPOSÉ ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
Abstract:
(EN) Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: Formula (I), in which each of variables L, R3, R4, Y, Z1, Z2 and Z3 is defined herein. Also disclosed is a method for treating a cancer with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.
(FR) L'invention concerne des composés de formule (I) ci-dessous et des sels pharmaceutiquement acceptables de ceux-ci : Formule (I), dans laquelle chacune des variables L, R3, R4, Y, Z1, Z2 et Z3 est définie dans la description. L'invention concerne également une méthode de traitement d'un cancer avec un composé de formule (I) ou un sel de celui-ci et une composition pharmaceutique le contenant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)