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1. (WO2019028096) METHODS AND COMPOSITIONS FOR TREATING CANCER
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Pub. No.: WO/2019/028096 International Application No.: PCT/US2018/044735
Publication Date: 07.02.2019 International Filing Date: 01.08.2018
IPC:
A61K 31/216 (2006.01) ,A61K 31/225 (2006.01) ,A61K 39/00 (2006.01) ,A61K 45/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
216
of acids having aromatic rings, e.g. benactizyne, clofibrate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
225
Polycarboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants:
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US/US]; 3601 Spruce Street Philadelphia, PA 19104, US
Inventors:
ERTL, Hildegund, C.J.; US
SALVINO, Joseph, M.; US
YELLAMELLI, Valli, V. S.; US
Agent:
BAK, Mary, E.; US
DUMINIAK, Robert, J.; US
KODROFF, Cathy, A.; US
SCHALLER, Colleen, M.; US
BAK, William; US
Priority Data:
62/540,33802.08.2017US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING CANCER
(FR) MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER
Abstract:
(EN) Methods for treating cancer are disclosed which comprise administering to a subject T cells which have been pretreated ex vivo or in vitro with fenofibric acid (FFA), an FFA prodrug, or a derivative thereof that has PPAR-α agonist activity. These compounds promote the use of fatty acid catabolism rather than glucose for energy and promote enhanced recovery of, and biomass production by, the pre-treated T cells. Still other methods comprise co-administering to a subject having a cancer characterized by a solid tumor an immunotherapeutic composition targeting an antigen or ligand on the tumor cell and the pretreated T cells. The method may also employ co-administration of a checkpoint inhibitor. Novel compositions comprise the pre-treated T cells. Novel FFA prodrugs are provided.
(FR) L'invention concerne des méthodes de traitement du cancer qui consistent à administrer à un sujet des lymphocytes T qui ont été pré-traités ex vivo ou in vitro avec de l'acide fénofibrique (FFA), un pro-médicament de FFA, ou un dérivé de celui-ci qui a une activité d'agoniste de PPAR-α. Ces composés favorisent l'utilisation du catabolisme des acides gras plutôt que du glucose pour l'énergie et favorisent une récupération améliorée des lymphocytes T pré-traités et une production de biomasse par ceux-ci. Encore d'autres méthodes consistent à co-administrer à un sujet atteint d'un cancer caractérisé par une tumeur solide une composition immunothérapeutique ciblant un antigène ou un ligand sur la cellule tumorale et les lymphocytes T pré-traités. La méthode peut également employer une co-administration d’un inhibiteur de point de contrôle. De nouvelles compositions comprennent les lymphocytes T pré-traités. L'invention concerne de nouveaux pro-médicaments de FFA.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)