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1. (WO2019028080) APOLIPOPROTEIN E ISOTYPE DETECTION BY MASS SPECTROMETRY
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Pub. No.: WO/2019/028080 International Application No.: PCT/US2018/044703
Publication Date: 07.02.2019 International Filing Date: 31.07.2018
IPC:
G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
QUEST DIAGNOSTICS INVESTMENTS LLC [US/US]; 500 Plaza Drive Secaucus, New Jersey 07094, US
Inventors:
WEBER, Darren; US
CLARKE, Nigel; US
Agent:
LOMPREY, Jeffrey R.; US
MEARA, Joseph P.; US
MCPARLAND, James; US
Priority Data:
62/539,47831.07.2017US
Title (EN) APOLIPOPROTEIN E ISOTYPE DETECTION BY MASS SPECTROMETRY
(FR) DÉTECTION DE L'ISOTYPE DE L'APOLIPOPROTÉINE E PAR SPECTROMÉTRIE DE MASSE
Abstract:
(EN) Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
(FR) L'invention concerne des procédés pour déterminer le phénotype de l'apolipoprotéine E (ApoE) dans un échantillon par spectrométrie de masse, le ou les allèles de l'ApoE présents dans l'échantillon étant déterminés à partir de l'identité des ions détectés par spectrométrie de masse. Selon un autre aspect, l'invention concerne des méthodes pour le diagnostic ou le pronostic de la maladie d'Alzheimer ou de la démence.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)