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1. (WO2019028045) PROTECTION AND SELECTIVE RELEASE OF COLORANT
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CLAIMS

1 . A selectively-releasable colorant composition comprising one or more resin particles having colorant molecules reversibly bound thereto via an association, wherein at least a portion of the colorant molecules dissociates with the one or more resin particles in response to one or more environmental stimuli.

2. The selectively-releasable colorant composition of claim 1 , wherein the one or more resin particles comprises one or more ion-exchange polymers.

3. The selectively-releasable colorant composition of claim 2, wherein the one or more ion-exchange polymers has been functionalized by one or more pretreatment agents.

4. The selectively-releasable colorant composition of claim 1 , wherein the colorant is suitable for use with an antiseptic solution containing one or more antiseptic agents.

5. The selectively-releasable colorant composition of claim 4, wherein the one or more antiseptic agents is selected from the group consisting of chlorhexidine gluconate, chlorhexidine acetate, chlorhexidine, chlorhexidine dihydrochloride, octenidine dihydrochloride, and combinations thereof.

6. The selectively-releasable colorant composition of claim 1 , wherein the colorant is a dye.

7. The selectively-releasable colorant composition of claim 1 , wherein the colorant is selected from the group consisting of FD&C Blue No. 1 (Brilliant Blue FCF), FD&C Blue No.2 (Indigo Carmine), FD&C Green No.3 (Fast Green FCF), FD&C Red No.3 (Erythrosine), FD&C Red No. 40 (Allura Red), FD&C Yellow No. 5 (Tartrazine), FD&C Yellow No. 6 (Sunset Yellow FCF), D&C Yellow No. 8 (Disodium Fluorescein), D&C Orange No. 4, and any combinations thereof.

8. The selectively-releasable colorant composition of claim 1 , wherein the association comprises one or more non-covalent interactions.

9. The selectively-releasable colorant composition of claim 8, wherein the non-covalent interactions are selected from the group consisting of ionic interactions, hydrogen bonds, halogen bonds, Van de Waals forces, dipole-dipole interactions, dipole-induced dipole interactions, London dispersion forces, π-π interactions, cation-π interactions, hydrophobic interactions, and combination thereof.

10. The selectively-releasable colorant composition of claim 9, wherein the association comprises at least two different non-covalent interactions.

1 1 . The selectively-releasable colorant composition of claim 1 , wherein the one or more environmental stimuli is selected from the group consisting of a molecular weight of one or more components of the environment, a temperature of the environment, a pH of the environment, a pKa of one or more ionizable groups in the environment, a hydrophobicity of one or more components of the environment, an ionic strength of one or more components of the environment, and combinations thereof.

12. The selectively-releasable colorant composition of claim 1 , wherein disassociation comprises a shift in an equilibrium between colorant molecules bound to the one or more resin particles and colorant molecules not bound to the one or more resin particles.

13. The selectively-releasable colorant composition of claim 1 , wherein the one or more environmental stimuli comprises at least two stimuli.

14. A method of making the selectively-releasable colorant composition of claim 1 comprising providing the one or more resin particles and combining the one or more resin particles with the colorant molecules, thereby binding the colorant molecules to the one or more resin particles via the association.

15. The method according to claim 14, wherein the one or more resin particles are prepared by combining ion-exchange resin particles with a pretreatment agent such that the ion-exchange resin particles are functionalized with one or more functional groups.

16. A method of coloring a product comprising combining the selectively-releasable colorant composition of claim 1 with a product to be colored.

17. The method of claim 16, wherein the combined product is sterilized and/or stored for a period of shelf life, wherein at least 65% of the colorant molecules are uncompromised by the sterilization and/or the period of shelf life.

18. The method of claim 17, wherein the combined product is sterilized using ethylene oxide.

19. A method of determining an identity of a product comprising combining the selectively-releasable colorant composition of claim 1 with a product and observing the product for color change.

20. An antiseptic applicator, wherein the applicator comprises:

one or more ampoules configured to contain an antiseptic solution; and

an application member,

wherein the applicator is provided with the selectively-releasable colorant composition of claim 1.

21 . The antiseptic applicator of claim 20 further comprising a fluid metering device, wherein the fluid metering device is impregnated with the selectively-releasable colorant composition.