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1. (WO2019028027) PROTEINS BINDING NKG2D, CD16 AND FLT3
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Pub. No.: WO/2019/028027 International Application No.: PCT/US2018/044610
Publication Date: 07.02.2019 International Filing Date: 31.07.2018
IPC:
A61K 39/395 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/46 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
Applicants:
DRAGONFLY THERAPEUTICS, INC. [US/US]; 35 Gatehouse Drive Waltham, MA 02451, US
Inventors:
CHANG, Gregory P.; US
CHEUNG, Ann F.; US
HANEY, William; US
LUNDE, Bradley M.; US
PRINZ, Bianka; US
Agent:
ASHRAF, Shovon; US
ARGENTIERI, Steven, R.; US
BRODOWSKI, Michael; US
BUCHMAN, Joshua, J.; US
Priority Data:
62/539,42131.07.2017US
Title (EN) PROTEINS BINDING NKG2D, CD16 AND FLT3
(FR) PROTÉINES SE LIANT À NKG2D, CD16 ET FLT3
Abstract:
(EN) Multi-specific binding proteins that bind NKG2D receptor, CD 16, and a tumor-associated antigen FLT3 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
(FR) L'invention concerne des protéines de liaison multi-spécifiques qui se lient au récepteur NKG2D, à CD16 et à un antigène FLT3 associé aux tumeurs, ainsi que des compositions pharmaceutiques et des méthodes thérapeutiques utiles dans le traitement du cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)