Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019028011) METHODS AND SYSTEMS FOR ALDEHYDE DETECTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/028011 International Application No.: PCT/US2018/044583
Publication Date: 07.02.2019 International Filing Date: 31.07.2018
IPC:
A61B 5/08 (2006.01) ,A61B 5/097 (2006.01) ,G01N 33/58 (2006.01) ,G01N 33/64 (2006.01) ,G01N 30/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
08
Measuring devices for evaluating the respiratory organs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
08
Measuring devices for evaluating the respiratory organs
097
Devices for facilitating collection of breath or for directing breath into or through measuring devices
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58
involving labelled substances
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
64
involving ketones
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
04
Preparation or injection of sample to be analysed
06
Preparation
Applicants:
THOMAS, Gerald [US/US]; US
NOLL, Charles [US/US]; US
LARA, Juven [US/US]; US
YOUNG, Brian [US/US]; US
CARLSEN, Craig [US/US]; US
BRANCHAUD, Bruce [US/US]; US
INGLE, James [US/US]; US
Inventors:
THOMAS, Gerald; US
NOLL, Charles; US
LARA, Juven; US
YOUNG, Brian; US
CARLSEN, Craig; US
BRANCHAUD, Bruce; US
INGLE, James; US
Agent:
PRENDERGAST, Paul J.; US
HEMENWAY, S. Craig; US
ASARO, Elissa; US
ATKINSON, David S.; US
SCHULTE, Timothy R.; US
NAGLE, Peter J.; US
GUGGENHEIMER, Benno M.; US
OSTERLOTH, Gregory W.; US
JARVIS, Peter M.; US
JONAS, Tamala R.; US
TREECE, Randolph E.; US
Priority Data:
62/539,87201.08.2017US
Title (EN) METHODS AND SYSTEMS FOR ALDEHYDE DETECTION
(FR) PROCÉDÉS ET SYSTÈMES DE DÉTECTION D'ALDÉHYDE
Abstract:
(EN) Provided herein are methods for detecting the presence of at least one carbonyl containing moiety in a sample and a system for performing the methods. The methods comprise the steps of: (a) dispensing labeling reagent solution onto a capture column, (b) pushing the sample through the column, (c) eluting labeled sample with methanol/water/HCI solution, (d) dispensing labeled sample onto a separation column, (e) separating the labeled aldehydes using isocratic methods or changing gradients of methanol (or other water miscible solvent) and water and/or buffer, and (f) detecting the labeled carbonyl containing moiety.
(FR) La présente invention concerne des procédés de détection de la présence d'au moins une entité contenant un carbonyle dans un échantillon et un système pour mettre en œuvre les procédés. Les procédés comprennent les étapes consistant à : (a) distribuer une solution de réactif de marquage sur une colonne de capture, (b) pousser l'échantillon à travers la colonne, (c) éluer l'échantillon marqué avec une solution de méthanol/eau/HCl, (d) distribuer l'échantillon marqué sur une colonne de séparation, (e) séparer les aldéhydes marqués à l'aide de procédés isocratiques ou de changements de gradient de méthanol (ou autre solvant miscible à l'eau) et d'eau et/ou de tampon, et (f) détecter l’entité contenant un carbonyle marqué.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)