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1. (WO2019027941) CARBAMOYL PHENYLALANINOL ANALOGS AND USES THEREOF
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Pub. No.: WO/2019/027941 International Application No.: PCT/US2018/044465
Publication Date: 07.02.2019 International Filing Date: 31.07.2018
IPC:
C07C 237/20 (2006.01) ,C07C 275/18 (2006.01) ,C07C 307/02 (2006.01) ,C07C 333/04 (2006.01) ,A61K 31/165 (2006.01) ,A61K 31/17 (2006.01) ,A61K 31/18 (2006.01) ,A61K 31/325 (2006.01) ,A61K 31/27 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02
having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
20
the carbon skeleton containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
275
Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04
having nitrogen atoms of urea groups bound to acyclic carbon atoms
18
of a saturated carbon skeleton containing rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
307
Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
02
Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
333
Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
02
Monothiocarbamic acids; Derivatives thereof
04
having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
17
having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
18
Sulfonamides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
325
Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
27
of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
JAZZ PHARMACEUTICALS INTERNATIONAL III LIMITED [GB/GB]; Clarendon House 2 Church Street Hamilton, HM11, BM
JAZZ PHARMACEUTICALS, INC. [US/US]; 3170 Porter Drive Palo Alto, California 94304, US (KN)
Inventors:
HURLEY, Fionn; IE
Agent:
SCHWARTZMAN, Robert A.; US
Priority Data:
62/539,08831.07.2017US
Title (EN) CARBAMOYL PHENYLALANINOL ANALOGS AND USES THEREOF
(FR) ANALOGUES DE CARBAMOYL PHÉNYLALANINOL ET LEURS UTILISATIONS
Abstract:
(EN) The present invention relates to carbamoyl phenylalaninol analogs and methods of using the same to treat disorders.
(FR) La présente invention concerne des analogues de carbamoyl-phénylalaninol ainsi que des procédés d’utilisation de ceux-ci pour traiter des troubles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)