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1. (WO2019027910) ADJUSTED MULTI-BIOMARKER DISEASE ACTIVITY SCORE FOR INFLAMMATORY DISEASE ASSESSMENT
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Pub. No.: WO/2019/027910 International Application No.: PCT/US2018/044396
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
A61K 35/14 (2015.01) ,A61K 35/16 (2015.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
16
Plasma; Serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
FLAKE, Darl [US/US]; US
GUTIN, Alexander [US/US]; US
LANCHBURY, Jerry [US/US]; US
CHERNOFF, David [US/US]; US
EASTMAN, Paul Scott [US/US]; US
HWANG, Ching Chang [US/US]; US
SASSO, Eric [US/US]; US
MYRIAD GENETICS, INC. [US/US]; 320 Wakara Way Salt Lake City, Utah 84108, US
Inventors:
FLAKE, Darl; US
GUTIN, Alexander; US
LANCHBURY, Jerry; US
CHERNOFF, David; US
EASTMAN, Paul Scott; US
HWANG, Ching Chang; US
SASSO, Eric; US
Agent:
ELLIS, Gregory C.; US
Priority Data:
62/538,95931.07.2017US
62/558,41314.09.2017US
Title (EN) ADJUSTED MULTI-BIOMARKER DISEASE ACTIVITY SCORE FOR INFLAMMATORY DISEASE ASSESSMENT
(FR) SCORE D'ACTIVITÉ DE MALADIE MULTI-BIOMARQUEUR AJUSTÉ POUR ÉVALUAER UNE MALADIE INFLAMMATOIRE
Abstract:
(EN) Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are methods of adjusting disease activity scores to account for variables that can influence such scores.
(FR) La présente invention concerne des méthodes servant à évaluer la réponse à un traitement de maladie inflammatoire. Les méthodes comprennent la mise en œuvre de dosages immunologiques pour produire des scores basés sur des données quantitatives d'expression de biomarqueurs liés à des biomarqueurs inflammatoires pour évaluer une activité de la maladie dans des maladies inflammatoires, par exemple la polyarthrite rhumatoïde. L'invention concerne également des méthodes d'ajustement de scores d'activité de la maladie pour tenir compte de variables qui peuvent influencer de tels scores.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)