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1. (WO2019027876) ANTIBODY-RESIN COUPLING APPARATUS AND METHODS
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Pub. No.: WO/2019/027876 International Application No.: PCT/US2018/044324
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
B01F 5/06 (2006.01) ,B01F 3/08 (2006.01) ,B01F 15/02 (2006.01) ,B01J 19/00 (2006.01) ,B01J 19/26 (2006.01) ,B01J 20/32 (2006.01) ,B29B 9/16 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
F
MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5
Flow mixers; Mixers for falling materials, e.g. solid particles
06
Mixers in which the components are pressed together through slits, orifices, or screens
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
F
MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
3
Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed
08
liquids with liquids; Emulsifying
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
F
MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
15
Accessories for mixers
02
Feed or discharge mechanisms
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19
Chemical, physical, or physico-chemical processes in general; Their relevant apparatus
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19
Chemical, physical, or physico-chemical processes in general; Their relevant apparatus
26
Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20
Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30
Processes for preparing, regenerating or reactivating
32
Impregnating or coating
B PERFORMING OPERATIONS; TRANSPORTING
29
WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
B
PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
9
Making granules
16
Auxiliary treatment of granules
Applicants:
SHIRE HUMAN GENETIC THERAPIES, INC. [US/US]; 300 Shire Way Lexington, MA 02421, US
Inventors:
TOSO, Robert; US
SPANGGORD, Richard; US
TAN, Mei; US
TAIRIOL, Van; US
LIN, Yekaterina; US
Agent:
MEYERS, Thomas, C.; US
LEONARDO, Mark, S.; US
HYDE, Zachary, D.; US
MAGGIN, Benjamin, D.; US
KOCK, Annie, J.; US
Priority Data:
62/541,60104.08.2017US
Title (EN) ANTIBODY-RESIN COUPLING APPARATUS AND METHODS
(FR) APPAREIL DE COUPLAGE ANTICORPS-RÉSINE ET PROCÉDÉS
Abstract:
(EN) An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.
(FR) Un appareil de couplage anticorps-résine qui active rapidement et efficacement des billes de résine et les couple à des anticorps, tout en empêchant la dégradation et la réticulation des billes, ce qui permet d'améliorer les processus de purification de la colonne en aval, l'extension de la durée de vie utile des billes de résine, et d'augmenter l'efficacité de capture de molécule des complexes résine-anticorps résultants, pour permettre une isolation et une purification améliorées de molécules de facteur VIII ou d'autres composés médicamenteux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)