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1. (WO2019027858) BENZO[b]THIOPHENE STING AGONISTS FOR CANCER TREATMENT
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Pub. No.: WO/2019/027858 International Application No.: PCT/US2018/044276
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
A61K 31/381 (2006.01) ,A61K 31/385 (2006.01) ,A61K 31/424 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
381
having five-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
385
having two or more sulfur atoms in the same ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42
Oxazoles
424
condensed with heterocyclic ring systems, e.g. clavulanic acid
Applicants:
CEMERSKI, Saso [US/US]; US (US)
CUMMING, Jared, N. [US/US]; US (US)
KOPINJA, Johnny, E. [US/US]; US (US)
PERERA, Samanthi, A. [US/US]; US (US)
TROTTER, Benjamin Wesley [US/US]; US (US)
TSE, Archie Ngai-Chiu [GB/US]; US (US)
MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Inventors:
CEMERSKI, Saso; US
CUMMING, Jared, N.; US
KOPINJA, Johnny, E.; US
PERERA, Samanthi, A.; US
TROTTER, Benjamin Wesley; US
TSE, Archie Ngai-Chiu; US
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
62/541,17404.08.2017US
Title (EN) BENZO[b]THIOPHENE STING AGONISTS FOR CANCER TREATMENT
(FR) AGONISTES BENZO[B]THIOPHÈNE DE STING POUR LE TRAITEMENT DU CANCER
Abstract:
(EN) Therapies comprising administering at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway, and the use of such therapies in the treatment of cell-proliferation disorders such as cancer, are disclosed herein.
(FR) L'invention concerne des thérapies comprenant l'administration d'au moins un composé benzo[b]thiophène qui active le stimulateur de la voie des gènes de l'interféron (STING), et l'utilisation de telles thérapies dans le traitement de troubles de la prolifération cellulaire tels que le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)