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1. (WO2019027847) SYNTHETIC EXTRACELLULAR VESICLES FOR NOVEL THERAPIES
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Pub. No.: WO/2019/027847 International Application No.: PCT/US2018/044251
Publication Date: 07.02.2019 International Filing Date: 27.07.2018
IPC:
A61K 39/395 (2006.01) ,A61K 49/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18
characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
Applicants:
ZHANG, Yong [US/US]; US
SHI, Xiaojing [US/US]; US
CHENG, Qinqin [US/US]; US
UNIVERSITY OF SOUTHERN CALIFORNIA [US/US]; 1150 South Olive Street, Suite 2300 Los Angeles, California 90015, US
Inventors:
ZHANG, Yong; US
SHI, Xiaojing; US
CHENG, Qinqin; US
Agent:
KONSKI, Antoinette F.; US
ARTINGER, Erika; US
SHELTON, Daniel; US
RAO, Photon; US
LIU, Cliff; US
DIEZ, Peter; US
Priority Data:
62/538,66929.07.2017US
Title (EN) SYNTHETIC EXTRACELLULAR VESICLES FOR NOVEL THERAPIES
(FR) VÉSICULES EXTRACELLULAIRES SYNTHÉTIQUES POUR NOUVELLES THÉRAPIES
Abstract:
(EN) Given developing resistance of tumor cells to current chemotherapeutic and targeted therapeutic agents, novel cancer therapies with enhanced potency and specificity are substantially required. Applicant has provided herein extracellular nanoparticle vesicles that redirect immune effector cells towards cancer cells for killing. Relative to conventional immunotherapeutic antibodies with defined orientation and geometry for their distinct antigen-binding arms, antibodies displayed on spherical exosomes can promote formation of immunological synapses as well as enhanced efficacy to activate immune cells.
(FR) Compte-tenu de la résistance croissante des cellules tumorales aux agents chimiothérapeutiques actuels et autres agents thérapeutiques ciblés, de nouvelles thérapies anticancéreuses ayant une puissance et une spécificité améliorées sont sensiblement requises. La présente invention concerne des vésicules de type nanoparticules extracellulaires qui redirigent les cellules immunitaires effectrices vers les cellules cancéreuses à des fins de destruction. Par rapport aux anticorps immunothérapeutiques classiques dont les bras distincts se liant à l'antigène ont une orientation et une géométrie définies, les anticorps présentés sur des exosomes sphériques selon l'invention peuvent favoriser la formation de synapses immunologiques et améliorer l'efficacité d'activation des cellules immunitaires.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)