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1. (WO2019027721) METHODS AND COMPOSITIONS FOR TREATMENT OF AMYLOID DEPOSITION DISEASES
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Pub. No.: WO/2019/027721 International Application No.: PCT/US2018/043374
Publication Date: 07.02.2019 International Filing Date: 24.07.2018
IPC:
A61K 39/395 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 535 West 116th Street New York, New York 10027, US
Inventors:
LENTZSCH, Suzanne; US
Agent:
CUNNINGHAM, Marina, F.; US
Priority Data:
62/539,82101.08.2017US
62/637,60902.03.2018US
Title (EN) METHODS AND COMPOSITIONS FOR TREATMENT OF AMYLOID DEPOSITION DISEASES
(FR) MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DES MALADIES À DÉPÔTS AMYLOÏDES
Abstract:
(EN) Methods and pharmaceutical compositions for treatment of amyloid deposition diseases using chimeric (e.g., mouse-human) antibody are disclosed, including a method for treating amyloid deposition diseases with cardiac involvement by administering pharmaceutical compositions comprising a chimeric anti-amyloid fibril antibody. The methods herein can improve myocardial function in patients diagnosed with light chain amyloid light chain amyloidosis (ALA) having a cardiac involvement in as little as three weeks after treatment.
(FR) L'invention concerne des méthodes et des compositions pharmaceutiques pour le traitement des maladies à dépôts amyloïdes utilisant un anticorps chimérique (p. ex., murin-humain), dont une méthode de traitement de maladies à dépôts amyloïdes ayant une composante cardiaque par administration de compositions pharmaceutiques comprenant un anticorps chimérique anti-fibrilles amyloïdes. Les méthodes selon l'invention peuvent améliorer la fonction myocardique dès trois semaines après le traitement.chez les patients chez lesquels on a diagnostiqué une amylose à chaînes légères (AL) caractérisée par des dépôts amyloïdes à chaînes légères.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)