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1. (WO2019027694) METHODS FOR TREATING HCV
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Pub. No.: WO/2019/027694 International Application No.: PCT/US2018/042992
Publication Date: 07.02.2019 International Filing Date: 20.07.2018
IPC:
A61K 31/454 (2006.01) ,A61K 31/4184 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
454
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4184
condensed with carbocyclic rings, e.g. benzimidazoles
Applicants:
ABBVIE INC. [US/US]; 1 North Waukegan Road North Chicago, Illinois 60064, US
Inventors:
COLLINS, Christine; US
FU, Bo; US
GULATI, Abhishek; US
KORT, Jens; US
KOSLOSKI, Matthew; US
LEI, Yang; US
LIN, Chih-Wei; US
LIU, Ran; US
MENSA, Federico; US
NG, Iok Chan; US
PILOT-MATIAS, Tami; US
PUGATCH, David; US
SHULMAN, Nancy S.; US
TRINH, Roger; US
VIANI, Rolando M.; US
WANG, Stanley; US
ZHANG, Zhenzhen; US
Agent:
SRIVASTAVA, Sonali; US
AHMED, Aamer; US
BAUDE, Eric; US
CHEN, Portia; US
CORBIN, Johanna; US
GESICKI, Glen; US
JOHANNES, Laura; US
SUN, Changxia; US
D'AMICO, Stephen C.; US
MONTGOMERY, Michael; US
Priority Data:
15/667,21202.08.2017US
Title (EN) METHODS FOR TREATING HCV
(FR) MÉTHODES DE TRAITEMENT DU VHC
Abstract:
(EN) The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.
(FR) La présente invention concerne des thérapies sans interféron pour le traitement du VHC. De préférence, la durée du traitement est réduite, par exemple à une durée n'excédant pas 12 semaines. Selon un aspect, le traitement comprend l’administration d’au moins deux agents antiviraux à action directe à un sujet ayant une infection par le VHC, le traitement durant 12 semaines et ne comprenant pas l’administration d’interféron ni de ribavirine, et lesdits au moins deux agents antiviraux à action directe comprenant (a) le composé 1 ou un sel pharmaceutiquement acceptable de ce composé et (b) le composé 2 ou un sel pharmaceutiquement acceptable de ce composé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)