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1. (WO2019027364) FUNGAL CELL WITH IMPROVED PROTEIN PRODUCTION CAPACITY
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Pub. No.: WO/2019/027364 International Application No.: PCT/SE2018/050779
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
C12N 15/80 (2006.01) ,C12P 1/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
80
for fungi
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
1
Preparation of compounds or compositions, not provided for in groups C12P3/-C12P39/121; General processes for the preparation of compounds or compositions by using micro-organisms or enzymes
02
by using fungi
Applicants:
BIOPETROLIA AB [SE/SE]; Chalmers Tekniska Högskola SE-412 96 Göteborg, SE
Inventors:
HUANG, Mingtao; SE
KRIVORUCHKO, Anastasia; SE
DAVID, Florian; SE
NIELSEN, Jens; SE
Agent:
AROS PATENT AB; Box 1544 SE-751 45 UPPSALA, SE
Priority Data:
1750968-831.07.2017SE
Title (EN) FUNGAL CELL WITH IMPROVED PROTEIN PRODUCTION CAPACITY
(FR) CELLULE FONGIQUE À CAPACITÉ DE PRODUCTION DE PROTÉINE AMÉLIORÉE
Abstract:
(EN) The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.
(FR) La présente invention concerne la fourniture de cellules fongiques génétiquement modifiées, telles que des cellules de levure avec une capacité améliorée à produire et à sécréter différentes protéines recombinantes. La capacité améliorée est obtenue par interruption du transport intracellulaire entre le Golgi et l'endosome. Dans des modes de réalisation particuliers, l'interruption est obtenue par la régulation négative ou la suppression du gène codant pour un homologue Tda3p. La cellule fongique et la méthode de l'invention permettent la production à grande échelle de protéines recombinantes dans des cellules fongiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)