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1. (WO2019027357) PEPTIDE EXHIBITING NEUROPROTECTIVE ACTIVITY ON A MODEL OF MPTP-INDUCED PARKINSONISM, AND PHARMACEUTICAL FORMULATION BASED ON SAME
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Pub. No.: WO/2019/027357 International Application No.: PCT/RU2018/050088
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
C07K 7/06 (2006.01) ,A61K 38/08 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
ЗОЛОТАРЕВ, Юрий Александрович ZOLOTAREV, Yurii Aleksandrovich [RU/RU]; RU
Inventors:
ЗОЛОТАРЕВ, Юрий Александрович ZOLOTAREV, Yurii Aleksandrovich; RU
ДАДАЯН, Александр Карэнович DADAYAN, Aleksandr Karenovich; RU
КОЗИК, Валерий Станиславович KOZIK, Valerij Stanislavovich; RU
Priority Data:
201712747701.08.2017RU
Title (EN) PEPTIDE EXHIBITING NEUROPROTECTIVE ACTIVITY ON A MODEL OF MPTP-INDUCED PARKINSONISM, AND PHARMACEUTICAL FORMULATION BASED ON SAME
(FR) PEPTIDE POSSÉDANT UNE ACTIVITÉ NEUROPROTECTRICE SUR UN MODÈLE DE PARKINSONISME INDUIT PAR MFTP ET COMPOSITION PHARMACEUTIQUE SUR LA BASE DE CELUI-CI
(RU) ПЕПТИД, ОБЛАДАЮЩИЙ НЕЙРОПРОТЕКТОРНОЙ АКТИВНОСТЬЮ НА МОДЕЛИ МФТП-ИНДУЦИРОВАННОГО ПАРКИНСОНИЗМА И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ
Abstract:
(EN) The invention relates to new biologically active compounds and more particularly to peptides exhibiting neuroprotective and normalising activity. Proposed is a use of a hexapeptide (1) of the structural formula threonyl-glycyl-glutamyl-homoserinyl-histidyl-arginyl-amide (Thr-Gly-Glu-Hse-His-Arg-NH2), as a neuroprotective and normalising agent. Also proposed is a new composition of a peptide-based pharmaceutical formulation containing a hexapeptide (2.5 g/l) as the active ingredient, a preservative in the form of Nipagin (1.0 g/l), and sodium chloride (10.0 g/l), with distilled water as the remainder. The composition is highly effective in low doses and is easy to use: application is in the form of nasal drops. The proposed pharmaceutical formulation can be used in medicine for the prevention and treatment of Parkinson's disease.
(FR) L'invention concerne de nouvelles compositions biologiquement actives et concrètement des peptides possédant une activité neuroprotectrice et normalisatrice. L'invention porte sur l’utilisation de l’hexapeptide (1) de formule développée thréonyl-glycyl-glutaminyl-homoséryl-histidyl-arginyl-amide (Thr-Gly-Glu-Hse-His-Arg-NH2) en tant que médicament neuroprotecteur et normalisant. L'invention porte sur une nouvelle composition pharmaceutique à base de peptide comportant en tant que principe actif de l’hexapeptide (2,5 g/l), un agent conservateur sous forme de nipagine (1,0 g/l), du chlorure de sodium (10,0 g/l), l’eau distillée constituant le reste. La composition est hautement efficace même à faibles doses et est simple à utiliser : elle peut s’utiliser sous forme de gouttes dans le nez. La composition pharmaceutique proposée peut s’utiliser en médecine humaine pour la prévention et le traitement de la maladie de Parkinson.
(RU) Изобретение относится к новым биологически активным соединениям, конкретно, к пептидам с нейропротекторной и нормализующей активностью. Предложено применение гексапептида (1) структурной формулы - Треонил-Глицил-Глутамил-Гомосеринил-Гистидил-Аргинил-амид (Thr-Gly-Glu-Hse-His-Arg-NH2) в качестве нейропротекторного и нормализующего средства. Предложен новый состав фармацевтической композиции на основе пептида, содержащей в качестве активного вещества гексапептид (2,5 г/л), консервант в виде нипагина (1,0 г/л), хлорид натрия (10,0 г/л) и вода дистиллированная - остальное. Состав высокоэффективен в низких дозах и прост в применении: используется в виде капель в нос. Предлагаемая фармацевтическая композиция может найти применение в медицине для профилактики и лечения болезни Паркинсона.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Russian (RU)
Filing Language: Russian (RU)