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1. (WO2019027299) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING VASCULAR DISORDERS INCLUDING MESENCHYMAL STEM CELL EXPRESSING HEPATOCYTE GROWTH FACTOR AS ACTIVE INGREDIENT
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Pub. No.: WO/2019/027299 International Application No.: PCT/KR2018/008903
Publication Date: 07.02.2019 International Filing Date: 06.08.2018
IPC:
A61K 35/28 (2015.01) ,C07K 14/475 (2006.01) ,C12N 5/0775 (2010.01) ,C12N 15/86 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
Applicants:
주식회사 에스엘바이젠 SLBIGEN INC. [KR/KR]; 경기도 성남시 분당구 대왕판교로 700 C동 7층 7F, Bldg. C, 700, Daewangpangyo-ro, Bundang-gu Seongnam-si, Gyeonggi-do 13488, KR
가톨릭대학교 산학협력단 THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 서울시 서초구 반포대로 222 222, Banpo-daero Seocho-gu Seoul 06591, KR
포항공과대학교 산학협력단 POSTECH ACADEMY-INDUSTRY FOUNDATION [KR/KR]; 경상북도 포항시 남구 청암로 77 77, Cheongam-ro, Nam-gu Pohang-si, Gyeongsangbuk-do 37673, KR
Inventors:
박훈준 PARK, Hun-Jun; KR
박봉우 PARK, Bong-Woo; KR
정수현 JUNG, Soo-Hyun; KR
이순민 LEE, Soon Min; KR
김혜연 KIM, Hey-yon; KR
조동우 CHO, Dong-Woo; KR
장진아 JANG, Jinah; KR
김석원 KIM, Seok-Won; KR
다스 산스크리타 DAS, Sanskrita; KR
Agent:
제일특허법인 FIRSTLAW P.C.; 서울시 서초구 마방로 60 60 Mabang-Ro, Seocho-gu, Seoul 06775, KR
Priority Data:
10-2017-009911204.08.2017KR
Title (EN) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING VASCULAR DISORDERS INCLUDING MESENCHYMAL STEM CELL EXPRESSING HEPATOCYTE GROWTH FACTOR AS ACTIVE INGREDIENT
(FR) COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE TROUBLES VASCULAIRES COMPRENANT UNE CELLULE SOUCHE MÉSENCHYMATEUSE EXPRIMANT UN FACTEUR DE CROISSANCE DES HÉPATOCYTES EN TANT QUE PRINCIPE ACTIF
(KO) 간세포성장인자를 발현하는 중간엽줄기세포를 유효성분으로 포함하는 혈관계 질환 예방 또는 치료용 약학 조성물
Abstract:
(EN) The present invention relates to a pharmaceutical composition for preventing or treating vascular disorders including a mesenchymal stem cell expressing a hepatocyte growth factor (HGF) protein as an active ingredient. This pharmaceutical composition for preventing or treating vascular disorders including a mesenchymal stem cell expressing an HGF protein as an active ingredient expresses HGF to induce vascularization, thereby stimulating the formation of capillaries and enhancing cardiac function. Therefore, the pharmaceutical composition according to the present invention can be usefully applied as pharmaceutical composition for preventing or treating vascular disorders, in particular, cardiovascular disorders.
(FR) La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement de maladies vasculaires, contenant une cellule souche mésenchymateuse exprimant une protéine de facteur de croissance des hépatocytes (HGF) comme principe actif. Cette composition pharmaceutique pour la prévention ou le traitement des troubles vasculaires comprenant une cellule souche mésenchymateuse exprimant une protéine HGF comme principe actif exprime HGF pour induire la vascularisation, ce qui stimule la formation de capillaires et améliore la fonction cardiaque. Par conséquent, la composition pharmaceutique selon la présente invention peut être utilement appliquée en tant que composition pharmaceutique pour la prévention ou le traitement des troubles vasculaires, en particulier des troubles cardiovasculaires.
(KO) 본 발명은 간세포성장인자 (HGF) 단백질을 발현하는 중간엽줄기세포를 유 효성분으로 포함하는 혈관계 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명의 HGF 단백질을 발현하는 중간엽줄기세포를 유효성분으로 포함하는 혈관 계 질환 예방 또는 치료용 약학 조성물은 HGF를 발현하여 혈관신생을 유도함으로 써 모세혈관의 형성을 촉진시키고 심기능을 향상시킨다. 따라서, 본 발명의 약학 조성물은 혈관계 질환, 특히 심혈관계 질환의 예방 또는 치료용 약학 조성물로 유용하게 활용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)