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1. (WO2019027244) COMPOSITION FOR IMPROVING PREVENTION AND TREATMENT OF FATTY LIVER CONTAINING AMOMUM VILOSUM EXTRACT.
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Pub. No.: WO/2019/027244 International Application No.: PCT/KR2018/008718
Publication Date: 07.02.2019 International Filing Date: 31.07.2018
IPC:
A61K 36/81 (2006.01) ,A23L 33/105 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
81
Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
[IPC code unknown for A23L 33/105]
Applicants:
주식회사 일원바이오 CORPORATION ILWONBIO [KR/KR]; 전라북도 익산시 왕궁면 동촌제길 110, 304호 304Ho, 110, Dongchonje-gil, Wanggung-myeon Iksan-Si Jeollabuk-do 54576, KR
국가식품클러스터지원센터 AGENCY FOR KOREA NATIONAL FOOD CLUSTER [KR/KR]; 전라북도 익산시 왕궁면 동촌제길 110 110, Dongchonje-gil, Wanggung-myeon Iksan-Si Jeollabuk-do 54576, KR
Inventors:
권강범 KWON, Kang Beom; KR
김하림 KIM, Ha Rim; KR
이금산 LEE, Guem San; KR
Agent:
특허법인 스마트 SMART PATENT LAW FIRM; 대전시 서구 둔산중로 74, 405호 405Ho, 74, Dunsanjung-ro Seo-Gu Daejeon 35240, KR
Priority Data:
10-2017-009849003.08.2017KR
Title (EN) COMPOSITION FOR IMPROVING PREVENTION AND TREATMENT OF FATTY LIVER CONTAINING AMOMUM VILOSUM EXTRACT.
(FR) COMPOSITION POUR AMÉLIORER LA PRÉVENTION ET LE TRAITEMENT DU FOIE GRAS CONTENANT UN EXTRAIT D'AMOMUM VILOSUM
(KO) 양춘사 추출물을 함유하는 지방간 예방 및 치료 개선 조성물
Abstract:
(EN) The present invention relates to a composition for improving the prevention and treatment of fatty liver containing an Amomum vilosum extract as an active ingredient. The present invention relates to a composition for improving the prevention and treatment of fatty liver, characterized in that the Amomum vilosum extract is extracted with water and is contained in an amount of 100 to 500 mg/kg on the basis of oral administration in a mouse. An objective of the present invention is to provide a composition for improving the prevention and treatment of fatty liver containing an Amomum vilosum extract as an active ingredient, through an inhibitory effect of the Amomum vilosum extract on the development of fatty liver and efficacies that suppress the mechanism of the fatty liver by means of in vitro and in vivo inhibition of TG in the liver, inhibition of ER stress-related gene expression, and inhibition of fat synthesis-related gene expression.
(FR) La présente invention concerne une composition pour la prévention le traitement du foie gras, la composition contenant un extrait de Amomum vilosum en tant que principe actif. La présente invention concerne une composition pour améliorer la prévention et le traitement du foie gras, caractérisé en ce que l'extrait d'Amomum vilosum est extrait avec de l'eau et est contenu en une quantité de 100 à 500 mg/kg sur la base d'une administration orale à une souris. La présente invention concerne une composition pour améliorer la prévention et le traitement du foie gras contenant un extrait d'Amomum vilosum en tant que principe actif, par l'intermédiaire d'un effet inhibiteur de l'extrait d'Amomum vilosum sur le développement du foie gras et des effets qui suppriment le mécanisme du foie gras au moyen d'une inhibition in vitro et in vivo de TG dans le foie, de l'inhibition de l'expression génique liée au stress du RE et de l'inhibition de l'expression génique associée à la synthèse des graisses.
(KO) 본 발명은 양춘사 추출물 유효성분을 함유하는 지방간 예방 및 치료 개선 조성물에 관한 것이다. 본 발명은 상기 양춘사 추출물은 물로 추출하는 것을 특징으로 하며, 마우스 경구 투여 기준으로 100 ~ 500mg/kg 포함되어 있는 것을 특징으로 하는 지방간 예방 및 치료 개선용 조성물에 관한 것이다. 본 발명은 양춘사 추출물의 지방간 생성에 대한 억제 효능 및 그 기전을 in vitro와 in vivo에서 간 내 TG억제, ER stress 관련 유전자 발현 억제, 지방합성 관련 유전자 발현을 억제하는 효능을 통해 양춘사 추출물 유효성분을 함유하는 지방간 예방 및 치료 개선 조성물을 제공하는 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)