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1. (WO2019027214) ALLOGENEIC MESENCHYMAL STEM CELL AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/027214 International Application No.: PCT/KR2018/008651
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
C12N 5/0775 (2010.01) ,A61K 35/28 (2015.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
Applicants:
인제대학교 산학협력단 INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 경상남도 김해시 인제로 197 (어방동, 인제대학교) (Inje University, Eobang-dong) 197, Inje-ro, Gimhae-si, Gyeongsangnam-do 50834, KR
주식회사 녹십자랩셀 GREEN CROSS LAB CELL CORPORATION [KR/KR]; 경기도 용인시 기흥구 이현로 30번길, 107 (보정동) (Bojeong-dong) 107, Ihyeon-ro 30beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do 16924, KR
Inventors:
서수길 SEO, Su Kil; KR
박하영 PARK, Ha Young; KR
이성민 LEE, Soung Min; KR
장원희 JANG, Won Hee; KR
유민주 YOO, Min Joo; KR
김정미 KIM, Jung Mi; KR
박대휘 PARK, Dae Hwi; KR
Agent:
두호특허법인 DOOHO IP LAW FIRM; 서울시 서초구 강남대로 51길 1, 7층 (서초동, 대현블루타워) (Daehyun Blue Tower, Seocho-dong) 7th Floor, 1, Gangnam-daero 51-gil, Seocho-gu, Seoul 06628, KR
Priority Data:
10-2017-009816402.08.2017KR
Title (EN) ALLOGENEIC MESENCHYMAL STEM CELL AND USE THEREOF
(FR) CELLULE SOUCHE MÉSENCHYMATEUSES ALLOGÉNIQUES ET UTILISATION ASSOCIÉE
(KO) 동종-중간엽 줄기세포 및 이의 용도
Abstract:
(EN) The present invention relates to an allogeneic mesenchymal stem cell and a use thereof, wherein, due to the inclusion of a step for treating a mesenchymal stem cell with an interferon gamma and a proteasome inhibitor, a mesenchymal stem cell can be produced in which transplant immunogenicity is suppressed, immunomodulating activity is enhanced, and congenital and adaptive immune cell activity can be suppressed. The mesenchymal stem cell does not transform into an inflammation-accelerating cell even when exposed to inflammation factors, thus allowing an immunosuppressive function to be stably maintained, and can prevent or treat various inflammatory disorders (for example, autoimmune disease, graft-versus-host-disease, etc.).
(FR) La présente invention concerne une cellule souche mésenchymateuse allogénique et une utilisation associée, où, du fait de l'inclusion d'une étape de traitement d'une cellule souche mésenchymateuse avec un interféron gamma et un inhibiteur de protéasome, une cellule souche mésenchymateuse peut être produite, dans laquelle l'immunogénicité de transplant est supprimée, l'activité immunomodulatrice est activée, et l'activité de cellule immunitaire congénitale et adaptative peut être supprimée. La cellule souche mésenchymateuse ne se transforme pas en une cellule accélérant l'inflammation même lorsqu'elle est exposée à des facteurs d'inflammation, ce qui permet de maintenir de manière stable une fonction immunosuppressive, et peut prévenir ou traiter divers troubles inflammatoires (par exemple, une maladie auto-immune, une maladie du greffon contre l'hôte, etc.).
(KO) 본 발명은 동종-중간엽 줄기세포 및 이의 용도에 관한 것으로, 인터페론 감마 및 프로테아좀 억제제를 중간엽 줄기세포에 처리하는 단계를 포함함으로써, 이식면역원성이 억제되고, 면역조절활성이 향상되며, 선천 및 적응 면역 세포의 활성을 억제할 수 있고, 염증인자에 노출되더라도 염증 촉진세포로 변질되지 않아 면역 억제 능력을 안정적으로 유지할 수 있고, 다양한 염증성 질환 (예컨대, 자가면역질환, 이식편대숙주질환 등)을 예방 또는 치료할 수 있는 중간엽 줄기세포를 제조할 수 있는, 본 발명은 동종-중간엽 줄기세포 및 이의 용도에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)