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1. (WO2019027203) DIHYDROXYPHENYL-BASED STEREOISOMER HAVING HSP90-INHIBITING ACTIVITY AND MEDICAL USE THEREOF
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Pub. No.: WO/2019/027203 International Application No.: PCT/KR2018/008613
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
A61K 31/496 (2006.01) ,A23L 33/10 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
[IPC code unknown for A23L 33/10]
Applicants:
계명대학교 산학협력단 INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY [KR/KR]; 대구시 달서구 달구벌대로 1095 1095, Dalgubeol-daero Dalseo-gu Daegu 42601, KR
Inventors:
서영호 SEO, Young Ho; KR
Agent:
특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM; 서울시 금천구 가산디지털1로151 이노플렉스1차 601호 #601 Innoplex 1 cha, 151Gasandigital 1-ro Geumcheon-gu Seoul 08506, KR
Priority Data:
10-2017-009792302.08.2017KR
10-2018-008793027.07.2018KR
Title (EN) DIHYDROXYPHENYL-BASED STEREOISOMER HAVING HSP90-INHIBITING ACTIVITY AND MEDICAL USE THEREOF
(FR) STÉRÉOISOMÈRE À BASE DE DIHYDROXYPHÉNYLE AYANT UNE ACTIVITÉ D'INHIBITION DE HSP90 ET SON UTILISATION MÉDICALE
(KO) HSP90 억제 활성을 갖는 디히드록시페닐계 입체이성질체 및 이의 의학적 용도
Abstract:
(EN) The present invention relates to a novel dihydroxyphenyl-based stereoisomer having Hsp90-inhibiting activity and a pharmaceutical composition or health functional food comprising the same. Being observed to exhibit an Hsp90-inhibiting effect that is too great to predict from and is 30 or more times higher than a racemate thereof, the stereoisomer can find useful applications in a pharmaceutical composition for prevention or treatment of an Hsp90-mediated disease selected from the group consisting of cancerous disease, neurodegenerative disease, and viral infection or in a health functional food for prevention or alleviation of an Hsp90-mediated disease selected from the group consisting of cancerous disease, neurodegenerative disease, and viral infection.
(FR) La présente invention concerne un nouveau stéréoisomère à base de dihydroxyphényle ayant une activité d'inhibition de Hsp90, et une composition pharmaceutique ou un aliment fonctionnel de santé le comprenant. Présentant un effet inhibiteur de Hsp90 qui est trop important à prédire, et qui est au moins 30 fois supérieur à un racémate de celui-ci, le stéréoisomère peut trouver des applications utiles dans une composition pharmaceutique pour la prévention ou le traitement d'une maladie médiée par Hsp90 choisie dans le groupe constitué par une maladie cancéreuse, une maladie neurodégénérative et une infection virale, ou dans un aliment fonctionnel de santé pour la prévention ou le soulagement d'une maladie médiée par Hsp90 choisie dans le groupe constitué par une maladie cancéreuse, une maladie neurodégénérative et une infection virale.
(KO) 본 발명은 Hsp90 억제활성을 갖는 신규 디히드록시페닐(dihydroxyphenyl)계 입체이성질체 및 이를 포함하는 약학 조성물 또는 건강기능식품에 관한 것으로, 상기 입체이성질체는 라세미 혼합물로부터 결코 예측할 수 없는 30배 이상의 탁월하게 우수한 Hsp90 억제 효과를 확인할 수 있으므로, 암 질환, 퇴행성 신경질환 및 바이러스 감염증으로 이루어진 군에서 선택된 어느 하나의 Hsp90 매개 질환 예방 또는 치료용 약학 조성물 또는, 예방 또는 개선용 건강기능식품으로 유용하게 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)