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1. (WO2019027167) ANTI-AGING OR SKIN-REGENERATING COMPOSITION COMPRISING PIPERONYLIC ACID AS EFFECTIVE INGREDIENT
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Pub. No.: WO/2019/027167 International Application No.: PCT/KR2018/008278
Publication Date: 07.02.2019 International Filing Date: 23.07.2018
IPC:
A61K 31/36 (2006.01) ,A23L 33/10 (2016.01) ,A61K 8/49 (2006.01) ,A61Q 19/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
357
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
36
Compounds containing methylenedioxyphenyl groups, e.g. sesamin
[IPC code unknown for A23L 33/10]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
49
containing heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
08
Anti-ageing preparations
Applicants:
포항공과대학교 산학협력단 POSTECH ACADEMY-INDUSTRY FOUNDATION [KR/KR]; 경상북도 포항시 남구 청암로 77 (지곡동) (Jigok-dong) 77, Cheongam-ro, Nam-gu, Pohang-si, Gyeongsangbuk-do 37673, KR
Inventors:
김경태 KIM, Kyong Tai; KR
이도현 LEE, Dohyun; KR
임진선 LIM, Jinsun; KR
Agent:
이명진 LEE, Myoung-Jin; KR
Priority Data:
10-2017-009801102.08.2017KR
Title (EN) ANTI-AGING OR SKIN-REGENERATING COMPOSITION COMPRISING PIPERONYLIC ACID AS EFFECTIVE INGREDIENT
(FR) COMPOSITION ANTI-VIEILLISSEMENT OU DE RÉGÉNÉRATION DE LA PEAU COMPRENANT DE L'ACIDE PIPÉRONYLIQUE EN TANT QUE PRINCIPE ACTIF
(KO) 피페로닐산을 유효성분으로 포함하는 항노화 또는 피부재생용 조성물
Abstract:
(EN) The present invention relates to a pharmaceutical composition comprising piperonylic acid as an effective ingredient for delaying skin senescence and regenerating the skin. A composition according to the present invention utilizes piperonylic acid that various plant species naturally contain therein and thus does not cause side effects. Piperonylic acid activates signals associated with cell survival, growth, and proliferation to exhibit the effect of increasing the resistance and survival of skin cells against external stimuli and enhancing the regeneration of the skin damaged due to external stimuli or senescence. In addition, piperonylic acid of the present invention has a similar function to EGF, but is stable and small in size in contrast to EGF. Thus, piperonylic acid of the present invention has the advantage of being able to easily move to the skin basal layer across the skin barrier and perform its function. Piperonylic acid of the present invention is expected to find applications in various fields including medicines, quasi-drugs, cosmetics, cosmetic substances, functional biomaterials, and functional food materials.
(FR) La présente invention concerne une composition pharmaceutique comprenant de l'acide pipéronylique en tant que principe actif permettant le retard de la sénescence de la peau et la régénération de la peau. Une composition selon la présente invention utilise de l'acide pipéronylique que diverses espèces végétales contiennent naturellement et ne provoque donc pas d'effets secondaires. L'acide pipéronylique active des signaux associés à la survie, la croissance et la prolifération cellulaire pour présenter un effet d'augmentation de la résistance et de la survie des cellules cutanées vis-à-vis de stimulus externes et d'amélioration de la régénération de la peau endommagée en raison de stimulus externes ou de sénescence. De plus, l'acide pipéronylique selon la présente invention a une fonction similaire à EGF, mais est stable et de petite taille par rapport à EGF. Ainsi, l'acide pipéronylique selon la présente invention a pour avantage de pouvoir se déplacer facilement vers la couche de base de peau à travers la barrière cutanée et d’exécuter sa fonction. Il est attendu que l'acide pipéronylique selon la présente invention trouve des applications dans divers domaines comprenant les médicaments, les quasi-médicaments, les produits cosmétiques, les substances cosmétiques, les biomatériaux fonctionnels et les matériaux alimentaires fonctionnels.
(KO) 본 발명은 피페로닐산을 유효성분으로 포함하는 항노화 또는 피부재생용 약학적 조성물 등에 관한 것으로서, 본 발명에 따른 조성물은 다양한 식물종이 자연적으로 함유하고 있는 피페로닐산을 이용한 것으로서 부작용이 없으며, 피페로닐산은 세포 생존(survival), 성장(growth), 및 증식(proliferation) 관련 신호를 활성화 시킴으로써, 외부 자극으로부터 피부세포의 저항력 및 생존력을 증가시키고, 외부 자극 또는 노화로 인해 손상받은 피부의 재생력을 증진시키는 효과가 있다. 또한, 본 발명의 피페로닐산은 EGF와 유사한 기능을 가지면서도 EGF와 달리 안정적이고 크기가 작아, 피부장벽을 통과하여 피부 기저층으로 쉽게 이동함으로써 그 기능을 수행할 수 있는 장점이 있는바, 본 발명의 피페로닐산은 의약용, 의약부외용, 화장료용, 향장소재용, 기능성 바이오 소재용 및 기능성 식품소재용 등 다양한 방면으로 이용이 가능할 것으로 기대된다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)