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1. (WO2019027005) METHOD FOR EVALUATING TUBERCULOSIS ONSET RISK SPECIFICALLY TO GENETIC LINEAGE OF MYCOBACTERIUM TUBERCULOSIS
Latest bibliographic data on file with the International Bureau    Submit observation
Pub. No.: WO/2019/027005 International Application No.: PCT/JP2018/029060
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
C12Q 1/6832 (2018.01) ,C12N 15/00 (2006.01) ,G01N 33/50 (2006.01) ,G01N 33/68 (2006.01)
[IPC code unknown for C12Q 1/6832]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
国立大学法人東京大学 THE UNIVERSITY OF TOKYO [JP/JP]; 東京都文京区本郷七丁目３番１号 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654, JP
国立研究開発法人理化学研究所 RIKEN [JP/JP]; 埼玉県和光市広沢２番１号 2-1, Hirosawa, Wako-shi, Saitama 3510198, JP
タイ国　ミニストリー　オブ　パブリック　ヘルス、デパートメント　オブ　メディカル　サイエンシス DEPARTMENT OF MEDICAL SCIENCES, MINISTRY OF PUBLIC HEALTH, THAILAND [TH/TH]; ムアン　ノンチャブリ　チワノン　ロード　８８／７ 88/7 Tiwanon Road, Muang, Nonthaburi 11000, TH
Inventors:
徳永　勝士 TOKUNAGA, Katsushi; JP
大前　陽輔 OMAE, Yosuke; JP
豊岡　理人 TOYOOKA, Rihito; JP
野内　英樹 YANAI, Hideki; JP
莚田　泰誠 MUSHIRODA, Taisei; JP
久保　充明 KUBO, Michiaki; JP
マハシリモンコン　スラカメ MAHASIRIMONGKOL, Surakameth; TH
Agent:
特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES; 東京都港区愛宕二丁目５－１　愛宕グリーンヒルズＭＯＲＩタワー３２階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2017-15029602.08.2017JP
Title (EN) METHOD FOR EVALUATING TUBERCULOSIS ONSET RISK SPECIFICALLY TO GENETIC LINEAGE OF MYCOBACTERIUM TUBERCULOSIS
(FR) PROCÉDÉS D’ÉVALUATION DU RISQUE D’APPARITION DE LA TUBERCULOSE SPÉCIFIQUEMENT À UNE LIGNÉE GÉNÉTIQUE DE MYCOBACTERIUM TUBERCULOSIS
(JA) 結核菌遺伝系統特異的に結核症発症のリスクを判定する方法
Abstract:
(EN) Provided is a method for evaluating an onset risk of tuberculosis on the basis of genetic information of a subject, said subject being infected with Mycobacterium tuberculosis, specifically to each genetic lineage of M. tuberculosis. The method comprises: identifying a base at a single nucleotide polymorphic site in the subject's genome relating to the onset of tuberculosis in the subject; typing the genetic lineage of M. tuberculosis latently infecting the subject; and then determining the risk of the onset of tuberculosis caused by the latently infecting M. tuberculosis in the subject specifically to the genetic lineage of M. tuberculosis.
(FR) La présente invention concerne un procédé d’évaluation d’un risque d’apparition de la tuberculose sur la base de l’information génétique d’un sujet, ledit sujet étant infecté par Mycobacterium tuberculosis, spécifiquement à chaque lignée génétique de M. tuberculosis. Le procédé comprend : l’identification d’une base au niveau d’un site de polymorphisme à nucléotide unique dans le génome du sujet concernant l’apparition de la tuberculose chez le sujet ; le typage de la lignée génétique de M. tuberculosis infectant de manière latente le sujet ; et ensuite la détermination du risque d’apparition de la tuberculose causé par l’infection latente par M. tuberculosis chez le sujet spécifiquement à la lignée génétique de M. tuberculosis.
(JA) 結核菌に感染している被験体において、結核菌遺伝系統ごとに特異的に、被験体の遺伝子情報に基づいて、結核症発症のリスクを判定する方法の提供。　被験体において、結核症の発症と関連している被験体ゲノムの一塩基多型部位の塩基を同定し、かつ被験体に潜伏感染している結核菌遺伝系統をタイピングし、結核菌遺伝系統特異的に、被験体において潜伏感染している結核菌により結核症を発症するリスクを判定する方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)