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1. (WO2019027003) HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/027003 International Application No.: PCT/JP2018/029045
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
C07D 207/14 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/4025 (2006.01) ,A61K 31/506 (2006.01) ,A61P 25/28 (2006.01) ,A61P 43/00 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14
Nitrogen atoms not forming part of a nitro radical
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
Applicants:
武田薬品工業株式会社 TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 大阪府大阪市中央区道修町四丁目1番1号 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Inventors:
藤本 辰彦 FUJIMOTO, Tatsuhiko; JP
力丸 健太郎 RIKIMARU, Kentaro; JP
福田 耕一朗 FUKUDA, Koichiro; JP
杉本 浩通 SUGIMOTO, Hiromichi; JP
松本 孝浩 MATSUMOTO, Takahiro; JP
梶田 雄一 KAJITA, Yuichi; JP
味上 達 MIKAMI, Satoshi; JP
宮野鼻 悠平 MIYANOHANA, Yuhei; JP
小池 竜樹 KOIKE, Tatsuki; JP
大仁 將揮 DAINI, Masaki; JP
荻野 正樹 OGINO, Masaki; JP
竹内 公平 TAKEUCHI, Kohei; JP
宮▲崎▼ 徹 MIYAZAKI, Tohru; JP
伊藤 吉輝 ITO, Yoshiteru; JP
▲徳▼永 礼仁 TOKUNAGA, Norihito; JP
杉本 貴裕 SUGIMOTO, Takahiro; JP
小田 恒夫 ODA, Tsuneo; JP
帆足 保孝 HOASHI, Yasutaka; JP
服部 靖志 HATTORI, Yasushi; JP
今村 圭佑 IMAMURA, Keisuke; JP
Agent:
高島 一 TAKASHIMA, Hajime; JP
鎌田 光宜 KAMADA, Mitsunori; JP
Priority Data:
2017-15068303.08.2017JP
Title (EN) HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
(FR) COMPOSÉ HÉTÉROCYCLIQUE ET SON APPLICATION
(JA) 複素環化合物およびその用途
Abstract:
(EN) The present invention provides a heterocyclic compound having orexin receptor type 2 agonist activity. In the present invention, a compound represented by formula (I) (in the formula, each symbol is as described in the specification) or a salt thereof has orexin receptor type 2 agonist activity and is useful as an agent for the prevention or treatment of narcolepsy.
(FR) La présente invention concerne un composé hétérocyclique ayant une activité agoniste du récepteur de type 2 de l'orexine. La présente invention concerne également un composé représenté par la formule (I) (dans la formule, chaque symbole est tel que décrit dans la description) ou un sel de celui-ci ayant une activité agoniste du récepteur de type 2 de l'orexine et qui est utile en tant qu'agent de prévention ou de traitement de la narcolepsie.
(JA) 本発明は、オレキシン2型受容体作動活性を有する複素環化合物を提供する。 本発明は、式(I):[式中、各記号は明細書記載のとおり] で表される化合物またはその塩は、オレキシン2型受容体作動活性を有し、ナルコレプシーの予防または治療剤として有用である。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)