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1. (WO2019026920) SUPER VERSATILE METHOD FOR PRESENTING CYCLIC PEPTIDE ON PROTEIN STRUCTURE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/026920 International Application No.: PCT/JP2018/028705
Publication Date: 07.02.2019 International Filing Date: 31.07.2018
IPC:
C12N 15/62 (2006.01) ,C07K 19/00 (2006.01) ,C12P 21/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
04
Cyclic or bridged peptides or polypeptides, e.g. bacitracin
Applicants:
国立大学法人東京大学 THE UNIVERSITY OF TOKYO [JP/JP]; 東京都文京区本郷七丁目3番1号 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654, JP
国立大学法人大阪大学 OSAKA UNIVERSITY [JP/JP]; 大阪府吹田市山田丘1番1号 1-1, Yamadaoka, Suita-shi, Osaka 5650871, JP
Inventors:
菅 裕明 SUGA, Hiroaki; JP
▲高▼木 淳一 TAKAGI, Junichi; JP
Agent:
稲葉 良幸 INABA, Yoshiyuki; JP
大貫 敏史 ONUKI, Toshifumi; JP
Priority Data:
2017-14862231.07.2017JP
Title (EN) SUPER VERSATILE METHOD FOR PRESENTING CYCLIC PEPTIDE ON PROTEIN STRUCTURE
(FR) PROCÉDÉ SUPER-POLYVALENT POUR PRÉSENTER UN PEPTIDE CYCLIQUE SUR UNE STRUCTURE PROTÉIQUE
(JA) 環状ペプチドをタンパク質構造に提示させる超汎用法
Abstract:
(EN) Provided is a method for presenting a cyclic peptide, which has a chemically crosslinked structure for forming an intramolecular cyclic structure, on a protein having a loop structure, said method comprising substituting the chemically crosslinked structure of the cyclic peptide by two amino acid residues constituting the loop structure to thereby fuse the cyclic peptide with the protein having the loop structure.
(FR) L'invention concerne un procédé de présentation d'un peptide cyclique, qui comprend une structure chimiquement réticulée pour former une structure cyclique intramoléculaire, sur une protéine ayant une structure en boucle, où ledit procédé comprend la substitution de la structure chimiquement réticulée du peptide cyclique par deux résidus acides aminés constituant la structure en boucle pour ainsi fusionner le peptide cyclique avec la protéine ayant la structure en boucle.
(JA) 本発明は、環状ペプチドを、ループ構造を有するタンパク質上に提示する方法であって、環状ペプチドは、分子内環状構造を形成するための化学架橋構造を有し、環状ペプチドの化学架橋構造を、ループ構造を構成する2つのアミノ酸残基に置き換えることにより、環状ペプチドを、ループ構造を有するタンパク質に融合させることを含む、方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)