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1. WO2019026920 - SUPER VERSATILE METHOD FOR PRESENTING CYCLIC PEPTIDE ON PROTEIN STRUCTURE

Publication Number WO/2019/026920
Publication Date 07.02.2019
International Application No. PCT/JP2018/028705
International Filing Date 31.07.2018
IPC
C12N 15/62 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12P 21/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
04Cyclic or bridged peptides or polypeptides, e.g. bacitracin
CPC
C07K 1/1075
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
107by chemical modification of precursor peptides
1072by covalent attachment of residues or functional groups
1075by covalent attachment of amino acids or peptide residues
C07K 14/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
C07K 16/247
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
244Interleukins [IL]
247IL-4
C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 2319/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
C07K 7/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
Applicants
  • 国立大学法人東京大学 THE UNIVERSITY OF TOKYO [JP]/[JP]
  • 国立大学法人大阪大学 OSAKA UNIVERSITY [JP]/[JP]
Inventors
  • 菅 裕明 SUGA, Hiroaki
  • ▲高▼木 淳一 TAKAGI, Junichi
Agents
  • 稲葉 良幸 INABA, Yoshiyuki
  • 大貫 敏史 ONUKI, Toshifumi
Priority Data
2017-14862231.07.2017JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) SUPER VERSATILE METHOD FOR PRESENTING CYCLIC PEPTIDE ON PROTEIN STRUCTURE
(FR) PROCÉDÉ SUPER-POLYVALENT POUR PRÉSENTER UN PEPTIDE CYCLIQUE SUR UNE STRUCTURE PROTÉIQUE
(JA) 環状ペプチドをタンパク質構造に提示させる超汎用法
Abstract
(EN) Provided is a method for presenting a cyclic peptide, which has a chemically crosslinked structure for forming an intramolecular cyclic structure, on a protein having a loop structure, said method comprising substituting the chemically crosslinked structure of the cyclic peptide by two amino acid residues constituting the loop structure to thereby fuse the cyclic peptide with the protein having the loop structure.
(FR) L'invention concerne un procédé de présentation d'un peptide cyclique, qui comprend une structure chimiquement réticulée pour former une structure cyclique intramoléculaire, sur une protéine ayant une structure en boucle, où ledit procédé comprend la substitution de la structure chimiquement réticulée du peptide cyclique par deux résidus acides aminés constituant la structure en boucle pour ainsi fusionner le peptide cyclique avec la protéine ayant la structure en boucle.
(JA) 本発明は、環状ペプチドを、ループ構造を有するタンパク質上に提示する方法であって、環状ペプチドは、分子内環状構造を形成するための化学架橋構造を有し、環状ペプチドの化学架橋構造を、ループ構造を構成する2つのアミノ酸残基に置き換えることにより、環状ペプチドを、ループ構造を有するタンパク質に融合させることを含む、方法を提供する。
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