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1. (WO2019026797) COMPOUND SUITABLE FOR DETECTING AGGREGATED PROTEIN
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Pub. No.: WO/2019/026797 International Application No.: PCT/JP2018/028279
Publication Date: 07.02.2019 International Filing Date: 27.07.2018
IPC:
C07D 417/06 (2006.01) ,A61K 49/00 (2006.01) ,G01T 1/161 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
G PHYSICS
01
MEASURING; TESTING
T
MEASUREMENT OF NUCLEAR OR X-RADIATION
1
Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
16
Measuring radiation intensity
161
Applications in the field of nuclear medicine, e.g. in vivo counting
Applicants:
国立大学法人静岡大学 NATIONAL UNIVERSITY CORPORATION SHIZUOKA UNIVERSITY [JP/JP]; 静岡県静岡市駿河区大谷836 836, Ohya, Suruga-ku, Shizuoka-shi, Shizuoka 4228529, JP
Inventors:
鳴海 哲夫 NARUMI Tetsuo; JP
今井 智之 IMAI Tomoyuki; JP
間瀬 暢之 MASE Nobuyuki; JP
佐藤 浩平 SATO Kohei; JP
Agent:
長谷川 芳樹 HASEGAWA Yoshiki; JP
諏澤 勇司 SUZAWA Yuji; JP
Priority Data:
2017-14799131.07.2017JP
Title (EN) COMPOUND SUITABLE FOR DETECTING AGGREGATED PROTEIN
(FR) COMPOSÉ APPROPRIÉ POUR DÉTECTER UNE PROTÉINE AGRÉGÉE
(JA) 凝集タンパク質の検出に適した化合物
Abstract:
(EN) A compound represented by formula (I) has a high selective capability to bind to aggregated proteins. (In the formula, R1 represents a C1-6 alkyl group, a C1-6 alkyl group substituted by a halogen atom, or –11CH3; R2 represents -CH3 or –11CH3, but R1 and R2 do not simultaneously represent –11CH3; one of Ra, Rb, Rc, and Rd is a halogen atom, and the remaining three are hydrogen atoms.)
(FR) La présente invention concerne un composé représenté par la formule (I) ayant une capacité sélective élevée pour se lier à des protéines agrégées. (Dans la formule, R1 représente un groupe alkyle en C1-6, un groupe alkyle en C1-6 substitué par un atome d'halogène, ou –11CH3 ; R2 représente -CH3 ou –11CH3, mais R1 et R2 ne représentent pas simultanément –11CH3 ; l'un de Ra, Rb, Rc, et Rd représente un atome d'halogène, et les trois restants sont des atomes d'hydrogène.)
(JA) 式(I)で表される化合物は、凝集タンパク質に対する選択的結合能が高い。  (式中、RはC1-6アルキル基、ハロゲン原子で置換されたC1-6アルキル基又は-11CHを表し、Rは-CH又は-11CHを表すが、R及びRは同時に-11CHを表さず、 R、R、R及びRのうちいずれか一つがハロゲン原子であり、残りの三つは水素原子である。)
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)