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1. (WO2019026071) ANTIMICROBIAL COATING MATERIAL COMPRISING NANOCRYSTALLINE CELLULOSE AND MAGNESIUM OXIDE AND METHOD OF PREPARATION THEREOF
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CLAIMS

We claim:

1. An antimicrobial chemical trap, wherein said antimicrobial chemical trap comprises a film characterized by an upper surface and a lower surface, said film comprising an antimicrobial layer comprising nanocrystalline cellulose (NCC) and particles of an antimicrobial substance selected from the group consisting of MgO, Mg(OH)2, mixtures thereof, and combinations thereof, said particles at least partially embedded within said film.

2. The antimicrobial chemical trap according to claim 1, wherein said particles of antimicrobial substance are at least partially coated with NCC.

3. The antimicrobial chemical trap according to claim 1, wherein said particles of antimicrobial substance are at least partially exposed on said upper surface.

4. The antimicrobial chemical trap according to claim 1, wherein at least a portion of said particles are disposed such that microbes contacting said upper surface will contact said particles.

5. The antimicrobial chemical trap according to claim 1, wherein said film is characterized by a thickness of between 0.5 μιη and 10 μιη.

6. The antimicrobial chemical trap according to claim 1, wherein said antimicrobial substance comprises nanoparticles.

7. The antimicrobial chemical trap according to claim 1, wherein said antimicrobial substance comprises particles characterized by a median diameter of between 0.5 μιη and 10 μιη.

8. The antimicrobial trap according to claim 1, wherein said film comprises at least one additive.

9. The antimicrobial trap according to claim 8, wherein said additive is selected from the group consisting of polymers, plasticizers, coloring agents, antioxidants, preservatives, and inert fillers.

10. The antimicrobial chemical trap according to claim 1, comprising an NCC layer in contact with said lower surface, said NCC layer comprising NCC but not MgO or Mg(OH)2.

11. The antimicrobial chemical trap according to claim 10, wherein said NCC layer comprises at least one additive.

12. The antimicrobial chemical trap according to claim 11, wherein said at least one additive is selected from the group consisting of polymers, plasticizers, coloring agents, antioxidants, preservatives, and inert fillers.

13. The antimicrobial chemical trap according to claim 1, comprising a thin upper NCC layer in contact with said upper surface, said thin upper NCC layer comprising NCC but not MgO or Mg(OH)2.

14. The antimicrobial chemical trap according to claim 1, wherein said film comprises between 1% and 50% by weight of said antimicrobial substance.

15. The antimicrobial chemical trap according to claim 14, wherein said film comprises between 10% and 20% by weight of said antimicrobial substance.

16. A method of controlling a microbial population, wherein said method comprises:

obtaining an antimicrobial chemical trap according to any one of claims 1 - 15; and, exposing a population of microbes to said upper surface of said antimicrobial trap, thereby exposing said microbes to antimicrobial activity arising from said antimicrobial substance.

17. The method according to claim 16, wherein said method comprises controlling a population of at least one microbe selected from the group consisting of E. coli, S. aureus, P. aeruginosa, Salmonella, and Listeria.

18. A method of producing an antimicrobial article, wherein said method comprises:

dispersing onto a substrate a first suspension, said first suspension comprising nanocrystalline cellulose (NCC) and an antimicrobial substance selected from the group consisting of MgO, Mg(OH)2, mixtures thereof, and combinations thereof, thereby producing an antimicrobial layer comprising an upper surface and a lower surface in which said antimicrobial substance is at least partially embedded within said antimicrobial layer; and,

drying said antimicrobial layer.

19. The method according to claim 18, wherein said first suspension comprises at least one additive.

20. The method according to claim 19, wherein said additive is selected from the group consisting of polymers, plasticizers, coloring agents, antioxidants, preservatives, and inert fillers.

21. The method according to claim 18, comprising:

dispersing a second suspension comprising nanocrystalline cellulose (NCC) but not

MgO or Mg(OH)2 onto said substrate, thereby producing an NCC layer; and, drying said NCC layer;

wherein said step of dispersing said first suspension comprises dispersing said first suspension onto said NCC layer.

22. The method according to claim 21, wherein at least one of said first suspension and said second suspension comprises at least one additive.

23. The method according to claim 21, wherein said step of dispersing said first suspension is performed subsequent to said step of drying said NCC layer.

24. The method according to claim 18, comprising dispersing a thin upper NCC layer on said upper surface, said thin upper NCC layer comprising NCC but not MgO or Mg(OH)2.

25. The method according to claim 18, wherein said substrate is not cationic.

26. The method according to claim 18, wherein said antimicrobial substance is in the form of nanoparticles.

27. The method according to claim 18, wherein said antimicrobial substance comprises particles having a median diameter of 1 and 10 μιη.

28. The method according to claim 18, wherein said first suspension comprises between 0.1% and 15% NCC (w/v).

29. The method according to claim 21, wherein at least one of said first suspension and said second suspension comprises between 0.1% and 3% NCC (w/v).

30. The method according to claim 18, wherein said first suspension comprises said antimicrobial substance and NCC in a ratio of between 10: 100 and 40:100 (w/w).

31. The method according to claim 18, wherein said first suspension comprises between 1% and 2% NCC (w/v), and said antimicrobial substance and said NCC are in a ratio of between 10: 100 and 20: 100 (w/w).

32. The method according to claim 18, comprising pretreating said substrate prior to said step of dispersing said first suspension.

33. The method according to claim 18, wherein said antimicrobial substance is not located between said antimicrobial layer and said substrate.

34. The method according to claim 18, wherein said substrate is selected from the group consisting of glass, polymers, hybrid materials, biomaterials, dielectric materials, fibers, paper, cardboard, metal surfaces, cement, concrete, plaster, wood, food surfaces, and any combination of the above.

35. The method according to claim 18, wherein said step of dispersing comprises dispersing said first suspension so as to produce an antimicrobial layer having a thickness of between 0.5 and ΙΟ μπι.

36. A method for applying an antimicrobial chemical trap to a substrate, comprising:

dispersing onto said substrate a first suspension, said first suspension comprising nanocrystalline cellulose (NCC) and an antimicrobial substance selected from the group consisting of MgO, Mg(OH)2, mixtures thereof, and combinations thereof, thereby producing an antimicrobial chemical trap comprising an antimicrobial layer; and,

drying said antimicrobial layer.

37. The method according to claim 36, wherein said step of dispersing is preceded by:

dispersing onto said substrate a second suspension comprising NCC but not MgO or

Mg(OH)2, thereby producing an NCC layer; and,

drying said NCC layer.

38. The method according to claim 36, wherein said antimicrobial substance is in a form selected from the group consisting of nanoparticles, microparticles, mixtures thereof, and combinations thereof.

39. The method according to claim 36, wherein said first suspension comprises at least one additive.

40. The method according to claim 39, wherein said additive is selected from the group consisting of polymers, plasticizers, coloring agents, antioxidants, preservatives, and inert fillers.

41. The method according to claim 36, wherein said substrate is not cationic.

42. The method according to claim 36, wherein said first suspension comprises between 0.1% and 15% NCC (w/v).

43. The method according to claim 37, wherein at least one of said first suspension and said second suspension comprises between 0.1% and 3% NCC (w/v).

44. The method according to claim 37, wherein at least one of said first suspension comprises at least one additive.

45. The method according to claim 36, wherein said first suspension comprises said antimicrobial substance and NCC in a ratio of between 10: 100 and 20:100 (w/w).

46. The method according to claim 36, wherein said first suspension comprises between 1% and 2% NCC (w/v), and said first substance and said NCC in a ratio of between 10: 100 and 20: 100 (w/v).

47. The method according to claim 36, comprising pretreating said substrate prior to said step of dispersing said first suspension.

48. The method according to claim 36, wherein said substrate is selected from the group consisting of glass, polymers, hybrid materials, biomaterials, dielectric materials, fibers, paper, cardboard, metal surfaces, cement, concrete, plaster, wood, food surfaces, and any combination of the above.

49. The method according to claim 36, wherein said step of dispersing comprises dispersing said first suspension so as to produce an antimicrobial layer having a thickness of between 0.5 and ΙΟ μπι.

50. The method according to claim 36, wherein said method does not include any step of dispersing said antimicrobial substance between said antimicrobial layer and said substrate.

51. An article comprising an antimicrobial coating, said article comprising:

a substrate; and,

an antimicrobial chemical trap comprising a film comprising an antimicrobial layer characterized by an upper surface and lower surface, said antimicrobial chemical trap comprising nanocrystalline cellulose (NCC) and an antimicrobial substance selected from the group consisting of MgO, Mg(OH)2, mixtures thereof, and combinations thereof embedded within said film said film disposed on at least one surface of said substrate such that said lower surface is in contact with said substrate.

52. The article according to claim 51, wherein said antimicrobial layer comprises at least one additive.

53. The article according to claim 52, wherein said additive is selected from the group consisting of polymers, plasticizers, coloring agents, antioxidants, preservatives, and inert fillers.

54. The article according to claim 51, wherein said antimicrobial chemical trap comprises an NCC layer comprising NCC but not MgO or Mg(OH)2 disposed between said substrate and said antimicrobial layer.

55. The article according to claim 51, wherein said antimicrobial chemical trap comprises a thin upper NCC layer comprising NCC but not MgO or Mg(OH)2 disposed on said upper surface.

56. The article according to claim 51, wherein said substrate is not cationic.

57. The article according to any one of claims 51 - 56, wherein said antimicrobial substance is in a form selected from the group consisting of nanoparticles, microparticles, mixtures thereof, and combinations thereof.

58. The article according to any one of claims 51 - 56, wherein said antimicrobial chemical trap comprises said antimicrobial substance and NCC in a ratio of between 10 : 100 and 20 : 100 (w/w).

59. The article according to any one of claims 51 - 56, wherein said substrate is selected from the group consisting of glass, polymers, hybrid materials, biomaterials, dielectric materials, fibers, paper, cardboard, metal surfaces, cement, concrete, plaster, wood, food surfaces, and any combination of the above.

60. The article according to any one of claims 51 - 56, wherein said substrate comprises at least one surface that has been pretreated to induce, permit, or hasten association of said surface and said layer.

61. The article according to any one of claims 51 - 56, wherein said antimicrobial layer is characterized by a thickness of between 0.5 and 10 μηι.

62. The article according to claim 54, wherein said layer comprising NCC is characterized by a thickness of between 0.5 and 10 μηι.

63. The article according to claim 51, produced according to the method of any one of claims

18 - 20, 24 - 28, or 30 - 35.

64. The article according to claim 54, produced according to the method of any one of claims

21 - 23 or 29.

65. The article according to any one of claims 51 - 56, wherein said article is selected from the group consisting of cloth, packaging, containers, products for wrapping and containing food, coatings for walls, coatings for work surfaces, coatings for shelves, and coatings for countertops.

66. An article comprising a substrate coated by an antimicrobial coating, wherein said antimicrobial coating is applied to said substrate according to the method of any one of claims 36 - 39.

67. A method for controlling a microbial population, comprising exposing a population of microbes to said antimicrobial layer of an article according to any one of claims 51 - 56.

68. A method for controlling a microbial population, comprising:

dispersing onto a substrate a first suspension, said first suspension comprising nanocrystalline cellulose (NCC) and an antimicrobial substance selected from the group consisting of MgO, Mg(OH)2, mixtures thereof, and combinations thereof, thereby producing an antimicrobial layer characterized by an upper surface and a lower surface, such that said antimicrobial substance is disposed in sufficient proximity to said upper surface such that microbes impinging on said upper surface will be exposed to antimicrobial activity by said antimicrobial substance; drying said antimicrobial layer; and,

placing said antimicrobial layer in a location such that said upper surface is accessible to microbes.

69. The method according to claim 68, comprising:

dispersing a second suspension comprising nanocrystalline cellulose (NCC) but not

MgO or Mg(OH)2 onto said substrate, thereby producing an NCC layer; and, drying said NCC layer;

wherein said step of dispersing said first suspension comprises dispersing said first suspension onto said NCC layer.

70. The method according to either one of claims 68 or 69, comprising a step of exposing a population of microbes to said antimicrobial layer.

71. The method according to either one of claims 68 or 69, wherein said method comprises controlling a population of at least one microbe selected from the group consisting of E. coli, S. aureus, P. aeruginosa, Salmonella, and Listeria.