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1. (WO2019026047) A COMPOSITION FOR USE IN THE PREVENTION AND/OR TREATMENT OF GASTRIC OR GASTROESOPHAGEAL DISEASES
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CLAIMS

1. A composition comprising the combination of at least one antacid, an extract from the fruit of a plant of the genus M sa, and at least one protease digestive enzyme.

2. The composition according to claim 1. wherein the at least one antacid is selected from the group consisting of carbonates, bicarbonates, citrates, hydroxides, metal oxides, trisilicates and any combination thereof, and the antacid is preferably present in the composition in an amount comprised between 5% and 90% by weight based on the total weight of the composition, more preferably in an amount comprised between 10% and 80% by weight based on the total weight of the composition.

3. The composition according to claim 1 or 2, wherein the plant of the genus Musa is Musa paradisiaca or Musa sapientum, and the extract is preferably present in the composition in an amount comprised between 2% and 90% by weight based on the total weight of the composition, more preferably in an amount comprised between 5% and 85% by weight based on the total weight of the composition.

4. The composition according to any of claims 1 to 3, wherein the at least one digestive enzyme is selected from the group consisting of papain, actinidain and bromelain, and the digestive enzyme is preferably present in the composition in an amount comprised between 0.1% and 40% by weight based on the total weight of the composition, more preferably in an amount comprised between 0.25% and 30% by weight based on the total weight of the composition.

5. The composition according to any of claims 1 to 4, which is formulated as an oral pharmaceutical formulation.

6. The composition according to any of claims 1 to 5, for use in the prevention and/or treatment of gastric or gastroesophageal diseases.

7. The composition for use according to claim 6, wherein the gastric or

gastroesophageal diseases are selected from dyspepsia, heartburn and gastroesophageal reflux disease.

8. A kit-of-parts for the sequential or simultaneous administration of at least one antacid, an extract from the fruit of a plant of the genus Musa, and at least one protease digestive enzyme, for use in the prevention and/or treatment of gastric or gastroesophageal diseases preferably selected from dyspepsia, heartburn and gastroesophageal reflux disease.

9. The kit-of-parts according to claim 8, wherein the at least one antacid is as defined in claim 2, the extract from the fruit of a plant of the genus Musa is as defined in claim 3, and the at least one protease digestive enzyme is as defined in claim 4.

10. The kit-of-parts according to claim 8 or 9, which is formulated as an oral pharmaceutical formulation.