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1. (WO2019025863) DRUG COMPOUND AND PURIFICATION METHODS THEREOF
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Pub. No.: WO/2019/025863 International Application No.: PCT/IB2018/000992
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
A61K 31/7084 (2006.01) ,A61K 9/19 (2006.01) ,F26B 5/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7084
Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
19
lyophilised
F MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
26
DRYING
B
DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
5
Drying solid materials or objects by processes not involving the application of heat
04
by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
06
the process involving freezing
Applicants:
OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 2-9 Kanda Tsukasa-machi, Chiyoda-ku, Tokyo, 101-8535, JP
Inventors:
JOSHI-HANGAL, Rajashree; US
DAVAR, Nipun; US
PRIEBE, Stephen, R.; US
Agent:
SHUSAKU YAMAMOTO; 17th Floor Grand Front Osaka Tower C 3-1 Ofuka-cho, Kita-ku Osaka, 530-0011, JP
Priority Data:
62/540,70603.08.2017US
Title (EN) DRUG COMPOUND AND PURIFICATION METHODS THEREOF
(FR) COMPOSÉ MÉDICAMENTEUX ET SES PROCÉDÉS DE PURIFICATION
Abstract:
(EN) The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.
(FR) L'invention concerne un procédé de préparation d'une composition pharmaceutique lyophilisée contenant un composé décrit dans le descriptif, ou un sel pharmaceutiquement acceptable de celui-ci. Le procédé consiste à dissoudre le composé dans un solvant comprenant du diméthylsulfoxyde et éventuellement un ou plusieurs co-solvants pour former une solution, et ensuite à éliminer le solvant et tout co-solvant par un procédé de lyophilisation. L'invention concerne également des compositions pharmaceutiques lyophilisées et leur utilisation en médecine et en particulier dans le traitement du cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)