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1. (WO2019025659) ANTI-PRESENILIN ANTIBODY FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER
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Pub. No.: WO/2019/025659 International Application No.: PCT/ES2018/070544
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07K 16/28 (2006.01) ,C07K 16/40 (2006.01) ,C07K 16/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants:
ALZHEIMUR 2012 S.L. [ES/ES]; C/ Extremadura 4, bajo 30565 Torres de Cotillas (Murcia), ES
IBSAL (INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE SALAMANCA) [ES/ES]; Hospital Virgen de la Vega, 10.ª planta Paseo de San Vicente, 58-182 37007 Salamanca, ES
Inventors:
GONZALEZ SARMIENTO, Rogelio; ES
RODRIGUEZ MANOTAS, Miguel; ES
FERNANDEZ MATEOS, Javier; ES
GALLAR RUIZ, Juan Carlos; ES
FLORENCIANO GOMEZ, David; ES
Agent:
PONS ARIÑO, Ángel; ES
Priority Data:
17382546.404.08.2017EP
Title (EN) ANTI-PRESENILIN ANTIBODY FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER
(FR) UTILISATION D'UN ANTICORPS ANTIPRÉSÉNILINE POUR LA PRÉVENTION ET/OU LE TRAITEMENT DU CANCER
(ES) USO DE UN ANTICUERPO ANTIPRESENILINA PARA LA PREVENCIÓN Y/O TRATAMIENTO DEL CÁNCER
Abstract:
(EN) The present invention relates to a specific antibody, or fragment thereof, against presenilin, and more specifically against luminal loop 1 of presenilin, for use in the prevention and/or treatment of cancer, by means of the administration of a therapeutically effective quantity of said antibody or a fragment thereof, or a pharmaceutical composition comprising same, to a cancer patient.
(FR) La présente invention concerne un anticorps ou un fragment de ce dernier, dirigé spécifiquement contre la préséniline et plus concrètement contre la boucle luminale de la préséniline, destiné à être utilisé dans la prévention et/ou le traitement du cancer, par administration d'une quantité thérapeutiquement efficace dudit anticorps ou d'un fragment de celui-ci, ou d'une composition pharmaceutique qui le comprend, à un sujet atteint du cancer.
(ES) La presente invención se refiere a un anticuerpo o un fragmento del mismo, específico contra la presenilina, y más concretamente contra el bucle luminal de la presenilina, para su uso en la prevención y/o tratamiento del cáncer, mediante la administración de una cantidad terapéuticamente efectiva de dicho anticuerpo o de un fragmento del mismo, o de una composición farmacéutica que lo comprenda, a un sujeto que padece cáncer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)