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1. (WO2019025639) DIAGNOSIS AND RISK STRATIFICATION OF FUNGAL INFECTIONS
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Pub. No.: WO/2019/025639 International Application No.: PCT/EP2018/071305
Publication Date: 07.02.2019 International Filing Date: 06.08.2018
IPC:
G01N 33/68 (2006.01) ,G01N 33/74 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74
involving hormones
Applicants:
B.R.A.H.M.S GMBH [DE/DE]; Neuendorfstrasse 25 16761 Henningsdorf, DE
UNIVERSITÄT HEIDELBERG [DE/DE]; Grabengasse 1 69117 Heidelberg, DE
Inventors:
BRENNER, Thorsten; DE
WEIGAND, Markus Alexander; DE
UHLE, Florian; DE
WILSON, Darius Cameron; DE
Agent:
SIMANDI, Claus; DE
Priority Data:
17185036.504.08.2017EP
Title (EN) DIAGNOSIS AND RISK STRATIFICATION OF FUNGAL INFECTIONS
(FR) DIAGNOSTIC ET STRATIFICATION DE RISQUES D'INFECTION FONGIQUE
Abstract:
(EN) The invention relates to a method for the diagnosis and/or risk stratification of invasive fungal infections (IFI) / invasive fungal diseases (IFD) and in particular associated with sepsis or septic shock, wherein a determination of the marker proadrenomedullin (proADM) or a partial peptide or fragment thereof, in particular midregional proadrenomedullin (MR-proADM), or contained in a marker combination (panel, cluster), is carried out from a patient to be examined. Furthermore, the invention relates to a diagnostic assay and a kit for carrying out the method.
(FR) L'invention concerne un procédé de diagnostic et/ou de stratification de risques d'infections fongiques invasives (IFI) ou de maladies fongiques invasives (IFD), plus précisément associées à une septicémie ou à un choc septique, une détermination de la proadrénomédulline marqueur (proADM), d'un peptide partiel ou d'un fragment de ce dernier, en particulier la proadrénomédulline midrégionale (MR-proADM), ou contenu dans une combinaison de marqueurs (panneau, groupe), étant réalisée sur un patient à examiner. L'invention concerne également un test diagnostic et un kit permettant de mettre en œuvre le procédé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)