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1. (WO2019025621) MATERIALS AND METHODS FOR INDUCING REGULATORY T CELLS
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Pub. No.: WO/2019/025621 International Application No.: PCT/EP2018/071201
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07K 14/435 (2006.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW [GB/GB]; Gilbert Scott Building University Avenue, Glasgow Lanarkshire G12 8QQ, GB
Inventors:
MAIZELS, Richard; GB
SMYTH, Danielle; GB
MCSORLEY, Henry; GB
Agent:
CRIPPS, Joanna; GB
ADDISS, John; GB
ANDREWS, Robert; GB
BAILEY, Sam; GB
BREARLEY, Sarah; GB
BURNS, Alexander; GB
CARLISLE, Julie; GB
CASLEY, Christopher; GB
CLEGG, Richard; GB
DALE, Elizabeth; GB
DENISON, Christopher; GB
DUNNE, Paul; GB
FORREST, Graham; GB
FURNIVAL, Tom; GB
GILL, Stephen; GB
GRAHAM, Emma; GB
GREEN, Katherine; GB
GREGORY, Adam; GB
HARRISON, Susan; GB
HAYES, Emily; GB
HODSDON, Stephen; GB
JOHNSON, Richard; GB
JONES, Rachel; GB
KEIRSTEAD, Tanis; GB
KIDDLE, Simon; GB
KREMER, Simon; GB
LEACH, James; GB
LENTHALL, Joseph; GB
LYONS, June; GB
MACIVER, Eleanor; GB
MCGUINN, Callum; GB
MOELLER, Christoph; GB
MOORE, Graeme; GB
NAYLOR, Matthew; GB
OXLEY, Rachel; GB
PARRY, Simon; GB
SALISBURY, Frances; GB
SMITH, Matthew; GB
STONER, Patrick; GB
SUTCLIFFE, Nicholas; GB
THORNTON, Dan; GB
TOLLERVEY, Rebecca; GB
WALTON, Seán; GB
WARD, Eliot; GB
WATSON, Robert; GB
WEBSTER, Jeremy; GB
WESCOTT, Rhiannon; GB
WILLS, Jonathan; GB
WYTENBURG, Wilhelmus; GB
Priority Data:
1712556.804.08.2017GB
Title (EN) MATERIALS AND METHODS FOR INDUCING REGULATORY T CELLS
(FR) MATÉRIAUX ET PROCÉDÉS PERMETTANT D'INDUIRE DES LYMPHOCYTES T RÉGULATEURS
Abstract:
(EN) The present invention concerns a structurally distinct immunosuppressive mimic of TGF-β that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-β mimic which fully replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-β mimic shares no homology to mammalian TGF-β or other members of the TGF-β family, but is distantly related to the complement control protein (CCP) superfamily.
(FR) La présente invention concerne un mimétique TGF-β immunosuppresseur structurellement distinct qui est un inducteur puissant de lymphocytes T régulateurs murins et humains et fournit un agent thérapeutique pour le traitement de troubles inflammatoires. L'invention concerne un nouveau mimétique de TGF-β parasite qui reproduit parfaitement les propriétés biologiques et fonctionnelles du TGF-β, y compris la liaison à des récepteurs de TGF-β de mammifère et l'induction de Foxp3+ Treg dans des lymphocytes T CD4+ murins et humains. Le mimétique de TGF-β de la présente invention n'a pas d'homologie avec le TGF-β de mammifère ou d'autres membres de la famille du TGF-β, mais est lié à distance à la superfamille des protéines de contrôle du complément (CCP).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)