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1. (WO2019025608) METHODS FOR TREATING LEUKAEMIA WITH AN NEURON-GLIAL ANTIGEN 2 INHIBITOR
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Pub. No.: WO/2019/025608 International Application No.: PCT/EP2018/071177
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07K 16/30 (2006.01) ,A61P 35/00 (2006.01) ,G01N 33/53 (2006.01) ,A61K 38/43 (2006.01) ,A61K 39/395 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
INSTITUTO DE INVESTIGACIÓN CONTRA LA LEUCEMIA JOSEP CARRERAS [ES/ES]; Muntaner, 383, 3º, 2ª E-08021 Barcelona, ES
Inventors:
MENÉNDEZ BUJÁN, Pablo; ES
BUENO UROZ, Clara; ES
LÓPEZ MILLÁN, Belén; ES
ROCA HO, Heleia; ES
PRIETO FERNÁNDEZ, Cristina; ES
Agent:
VÁZQUEZ VÁZQUEZ, Irene; ES
Priority Data:
17382551.404.08.2017EP
Title (EN) METHODS FOR TREATING LEUKAEMIA WITH AN NEURON-GLIAL ANTIGEN 2 INHIBITOR
(FR) MÉTHODES DE TRAITEMENT DE LA LEUCÉMIE AU MOYEN D'UN INHIBITEUR DE L'ANTIGÈNE 2 DU NEURONE-GLIALE
Abstract:
(EN) The invention relates to a neuron-glial antigen 2 (NG2) inhibitor for use in the treatment of leukaemia. Additionally, the invention relates to in vitro methods for designing a customized therapy in a subject suffering from leukaemia based on determining the levels of NG2 and also to a method of determining whether a leukemic tumor is resistant or sensitive to chemotherapy based on determining the levels of NG2. The invention also relates to a combination comprising a neuron-glial antigen 2 (NG2) inhibitor and one or more therapeutic agents useful in the treatment of leukaemia.
(FR) L'invention concerne un inhibiteur de l'antigène 2 du neurone-gliale (NG2) destiné à être utilisé dans le traitement de la leucémie. L'invention concerne également des procédés in vitro de conception d'une thérapie adaptée chez un sujet souffrant de leucémie sur la base de la détermination des niveaux de NG2 ainsi qu'un procédé permettant de déterminer si une tumeur leucémique est résistante ou sensible à la chimiothérapie sur la base de la détermination des niveaux de NG2. L'invention concerne en outre une combinaison comprenant un inhibiteur de l'antigène 2 du neurone-gliale (NG2) et un ou plusieurs agents thérapeutiques utiles dans le traitement de la leucémie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)