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1. (WO2019025607) NOVEL ASSAY OF HDL FUNCTION
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Pub. No.: WO/2019/025607 International Application No.: PCT/EP2018/071172
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C12Q 1/44 (2006.01) ,A61K 31/00 (2006.01) ,G01N 33/92 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
44
involving esterase
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92
involving lipids, e.g. cholesterol
Applicants:
SORBONNE UNIVERSITE [FR/FR]; 21 rue de l'école de médecine 75006 PARIS, FR
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101 rue de Tolbiac 75013 PARIS, FR
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS [FR/FR]; 3 avenue Victoria 75004 PARIS, FR
Inventors:
KONTUSH, Anatol; FR
Agent:
GEVERS & ORES (GROUPEMENT 92); 41 Avenue de Friedland 75008 Paris, FR
Priority Data:
17306042.704.08.2017EP
Title (EN) NOVEL ASSAY OF HDL FUNCTION
(FR) NOUVEAU DOSAGE DE LA FONCTION HDL
Abstract:
(EN) The present invention relates to a method for predicting or diagnosing a cardiovascular disease or a metabolic disease associated with cardiovascular disease by determining the capacity of high- density lipoprotein (HDL) to acquire surface lipids of triglyceride-rich lipoprotein (TGRL) during lipolysis. The present invention also relates to a HDL-targeting compound for use in the prevention or the treatment of a subject which has been classified as being likely to respond by the method determining the capacity of HDL to acquire surface lipids of TGRL.
(FR) La présente invention concerne un procédé de prédiction ou de diagnostic d'une maladie cardiovasculaire ou d'une maladie métabolique associée à une maladie cardiovasculaire par détermination de la capacité de la lipoprotéine haute densité (HDL) à acquérir des lipides de surface de la lipoprotéine riche en triglycérides (TGRL) pendant la lipolyse. La présente invention concerne également un composé de ciblage de HDL destiné à être utilisé dans la prévention ou le traitement d'un sujet qui a été classé comme étant susceptible de répondre par le procédé déterminant la capacité de HDL à acquérir des lipides de surface de TGRL.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)