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1. (WO2019025521) NEW POLYMORPHIC FORM OF A PYRAZINO[2,3-h][3]BENZAZEPINE DERIVATIVE
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Pub. No.: WO/2019/025521 International Application No.: PCT/EP2018/070957
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
C07D 471/08 (2006.01) ,A61K 31/4985 (2006.01) ,A61P 25/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
08
Bridged systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
30
for treating abuse or dependence
34
Tobacco-abuse
Applicants:
MEDICHEM, S.A. [ES/ES]; Fructuós Gelabert, 6-8 E-08970 Sant Joan Despí, Barcelona, ES
Inventors:
DURAN LÓPEZ, Ernesto; ES
CARRERAS I VILAGRAN, Marçal; ES
Agent:
CARBONELL VALLÈS, Enric; ES
Priority Data:
17382540.703.08.2017EP
Title (EN) NEW POLYMORPHIC FORM OF A PYRAZINO[2,3-h][3]BENZAZEPINE DERIVATIVE
(FR) NOUVELLE FORME POLYMORPHE D'UN DÉRIVÉ DE PYRAZINO[2,3-H][3]BENZAZÉPINE
Abstract:
(EN) The present invention relates to a novel polymorphic form of varenicline fumarate, to processes for their preparation,to pharmaceutical compositions comprising the same and to their therapeutic uses.
(FR) La présente invention concerne une nouvelle forme polymorphe de fumarate de varénicline, des procédés pour leur préparation, des compositions pharmaceutiques les comprenant et leurs utilisations thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)