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1. (WO2019025485) MICROORGANISM FOR PRODUCING HUMAN MILK OLIGOSACCHARIDE
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Pub. No.: WO/2019/025485 International Application No.: PCT/EP2018/070857
Publication Date: 07.02.2019 International Filing Date: 01.08.2018
IPC:
C07K 14/245 (2006.01) ,C07K 14/435 (2006.01) ,C12P 19/18 (2006.01) ,C12N 9/10 (2006.01) ,A23L 33/00 (2016.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
24
from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
245
Escherichia (G)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
18
produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
[IPC code unknown for A23L 33]
Applicants:
OLIGOSCIENCE BIOTECHNOLOGY GMBH [DE/DE]; Zur Davert 7 59387 Ascheberg, DE
Inventors:
PERACHA, Max; DE
WEMHOFF, Sabrina; DE
MEINHARDT, Friedhelm; DE
Agent:
HOFFMANN EITLE PATENT- UND RECHTSANWÄLTE PARTMBB; Arabellastraße 30 81925 Munich, DE
Priority Data:
17184232.101.08.2017EP
Title (EN) MICROORGANISM FOR PRODUCING HUMAN MILK OLIGOSACCHARIDE
(FR) MICRO-ORGANISME DE PRODUCTION D'OLIGOSACCHARIDE DE LAIT HUMAIN
Abstract:
(EN) Human milk oligosaccharides (HMOs) may be used e.g. as functional ingredients in infant nutrition, medical nutrition, functional foods and animal feed. There is still a need of improved means of producing HMOs. The present invention provides genetically modified microorganisms for the improved production of HMOs and HMO production methods using the same. The microorganisms of the invention may have one or more yield-enhancing modifications, including an inducible lysis system, which allows for the easy extraction of intracellular and extracellular HMOs, lactose permease mutants, which may increase intracellular lactose levels, or chaperones, which may increase intracellular availability of key enzymes for the production of HMOs.
(FR) L'invention concerne un micro-organisme permettant de produire des oligosaccharides de lait humain (HMO) pouvant être utilisés par exemple en tant qu'ingrédients fonctionnels en alimentation infantile, nutrition médicale, aliments fonctionnels et alimentation pour animaux. Il existe encore un besoin pour améliorer les moyens de production de HMO. La présente invention porte sur des micro-organismes génétiquement modifiés permettant une production améliorée de HMO, et sur des procédés de production de HMO les utilisant. Les micro-organismes de l'invention peuvent présenter une ou plusieurs modification(s) renforçant le rendement, y compris un système de lyse inductible, qui facilite l'extraction des HMO intracellulaires et extracellulaires, des mutants de la lactose perméase, ce qui peut augmenter les niveaux de lactose intracellulaire, ou chaperons, susceptibles d'augmenter la disponibilité intracellulaire des enzymes clés pour la production de HMO.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)