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1. (WO2019025474) MODULATION OF ENDOCANNABINOID SYSTEM AND USES THEREOF IN THE CONTEXT OF INDUCED PLURIPOTENT STEM CELL-BASED APPLICATIONS AND THERAPY FOR CARDIOMYOPATHIES
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Pub. No.: WO/2019/025474 International Application No.: PCT/EP2018/070817
Publication Date: 07.02.2019 International Filing Date: 01.08.2018
IPC:
A61P 21/00 (2006.01) ,A61K 31/05 (2006.01) ,A61K 31/164 (2006.01) ,A61K 31/232 (2006.01) ,A61K 31/352 (2006.01) ,A61P 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
164
of a carboxylic acid with an aminoalcohol, e.g. ceramides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
23
of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232
having three or more double bonds, e.g. etretinate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants:
CENTRO CARDIOLOGICO MONZINO S.P.A. [IT/IT]; Via Filodrammatici 10 20121 Milano (MI), IT
UNIVERSITÀ DEGLI STUDI DI MILANO [IT/IT]; Via Festa del Perdono 7 20122 Milano (MI), IT
Inventors:
POMPILIO, Giulio; IT
GOWRAN, Aoife; IT
Agent:
TURRI, Elisa; IT
CAPASSO, Olga; IT
TRILLAT, Anne-Cécile; IT
Priority Data:
17184463.202.08.2017EP
Title (EN) MODULATION OF ENDOCANNABINOID SYSTEM AND USES THEREOF IN THE CONTEXT OF INDUCED PLURIPOTENT STEM CELL-BASED APPLICATIONS AND THERAPY FOR CARDIOMYOPATHIES
(FR) MODULATION D'UN SYSTÈME ENDOCANNABINOÏDE ET SES UTILISATIONS DANS LE CONTEXTE D'APPLICATIONS BASÉES SUR DES CELLULES SOUCHES PLURIPOTENTES INDUITES ET THÉRAPIE POUR CARDIOMYOPATHIES
Abstract:
(EN) The present invention relates to modulators of at least one endocannabinoid system component for use in i) the prevention and/or treatment of muscular dystrophy (MD) cardiomyopathy or other cardiomyopathies, and to pharmaceutical compositions comprising them, ii) the optimization of somatic cell reprogramming and control of CMs-d-iPSCs cell-identity, and iii) a therapeutic screening tool for modulators of at least one component of the endocannabinoid system for the treatment of MD cardiomyopathy or other cardiomyopathies.
(FR) La présente invention concerne des modulateurs d'au moins un composant de système endocannabinoïde pour une utilisation dans i) la prévention et/ou le traitement d'une cardiomyopathie de type dystrophie musculaire (MD) ou autres cardiomyopathies, et des compositions pharmaceutiques les comprenant, ii) l'optimisation de la reprogrammation des cellules somatiques et le contrôle d'identité des cellules CM-d-iPSC, et iii) un outil de criblage thérapeutique pour identifier des modulateurs d'au moins un composant du système endocannabinoïde pour le traitement de la cardiomyopathie MD ou autres cardiomyopathies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)