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1. (WO2019025324) PHOSPHOLIPID ANALOGUES
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Pub. No.: WO/2019/025324 International Application No.: PCT/EP2018/070481
Publication Date: 07.02.2019 International Filing Date: 27.07.2018
IPC:
A61P 25/16 (2006.01) ,A61K 31/661 (2006.01) ,C07F 9/09 (2006.01) ,C07F 9/10 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
661
Phosphorus acids or esters thereof not having P-C bonds, e.g. fosfosal, dichlorvos, malathion
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
09
Esters of phosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
09
Esters of phosphoric acids
10
Phosphatides, e.g. lecithin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
KARL-FRANZENS-UNIVERSITÄT GRAZ [AT/AT]; Universitätsplatz 3 8010 Graz, AT
UNIVERSITY OF CHICAGO [US/US]; 5801 S. Ellis Avenue Chicago, Illinois 60637, US
Inventors:
BIRUKOV, Konstantin; US
BIRUKOVA, Anna; US
BOCHKOV, Valery; AT
OSKOLKOVA, Olga; AT
Agent:
SCHWARZ & PARTNER PATENTANWÄLTE OG; Wipplingerstrasse 30 1010 Wien, AT
PFÖSTL, Andreas; AT
Priority Data:
15/667,89303.08.2017US
Title (EN) PHOSPHOLIPID ANALOGUES
(FR) ANALOGUES DE PHOSPHOLIPIDES
Abstract:
(EN) The present invention relates to a compound having a structure according to formula (I) or a salt thereof, wherein : R1 is a branched or linear alkyl, acyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, or hydroxy-alkinyl residue comprising 6 to 30 carbon atoms, R2 is selected from the group consisting of : a) an alkyl residue comprising 1 to 10 carbon atoms and comprising a terminal or cyclic quaternary ammonium, b) an alkyl residue comprising 1 to 10 carbon atoms and comprising a terminal amino group and/or 1 to 3 hydroxyl groups, c) an amino acid residue, d) a five or six carbon sugar and e) H, R3 is a residue selected from the group consisting of an alkyl, alkenyl, prostanyl-dialkyl, furanyl-dialkyl, cyclobutyl-dialkyl, cycloalkyl and aryl group of 2 to 40 carbon atoms length and comprising at least one keto group, epoxy group, aldehyde group, peroxy group, hydroperoxy group, hydroxyl group or a free carboxyl group, L1 is selected from the group consisting of O, NH, S, CH2, (aa), (bb), (cc), (dd), (ee), (ff), (gg), (hh), (ii), (jj), (kk), (ll), (mm), or (nn), L2 is an amide group or an ether group, X and Z are independently O, S or CH2, and Y is selected from the group consisting of O and S.
(FR) La présente invention concerne un composé ayant une structure selon la formule (I) ou un sel de celui-ci, dans laquelle : R1 représente un résidu alkyle, acyle, alcényle, hydroxyalkyle, hydroxyalcényle ou hydroxy-alcinyle linéaire ou ramifié comportant 6 à 30 atomes de carbone, R2 est choisi dans le groupe constitué par : a) un résidu alkyle comprenant 1 à 10 atomes de carbone et comprenant un ammonium quaternaire terminal ou cyclique, b) un résidu alkyle comprenant 1 à 10 atomes de carbone et comprenant un groupement amino terminal et/ou 1 à 3 groupements hydroxyle, c) un résidu d’acide aminé, d) un sucre à cinq ou six carbones et e) H, R3 représente un résidu choisi dans le groupe constitué des groupements alkyle, alcényle, prostanyl-dialkyle, furanyl-dialkyle, cyclobutyl-dialkyle, cycloalkyle et aryle d’une longueur de 2 à 40 atomes de carbone et comprenant au moins un groupement céto, époxy, aldéhyde, peroxy, hydroperoxy, hydroxyle ou carboxyle libre, L1 est choisi dans le groupe constitué par O, NH, S, CH2, (aa), (bb), (cc), (dd), (ee), (ff), (gg), (hh), (ii), (jj), (kk), (ll), (mm) ou (nn), L2 représente un groupement amide ou un groupement éther, chacun des chaînons X et Z représente indépendamment O, S ou CH2, et Y est choisi dans le groupe constitué par O et S.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)