Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019025299) THREE-DIMENSIONAL STRUCTURE-BASED HUMANIZATION METHOD
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/025299 International Application No.: PCT/EP2018/070372
Publication Date: 07.02.2019 International Filing Date: 27.07.2018
IPC:
C07K 16/24 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/46 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
HOFFMANN-LA ROCHE INC. [US/US]; Great Notch, 150 Clove Road, 8th Floor Little Falls, New Jersey 07424, US (US)
Inventors:
AUER, Johannes; DE
GEORGES, Guy; DE
KLOSTERMANN, Stefan; DE
SCHAEFER, Wolfgang; DE
Agent:
SKOLAUT, Alexander; DE
BURGER, Alexander; DE
EISENMANN, Ulrike; DE
GOEHRING, Frank; DE
HILDEBRANDT, Martin; DE
JENNI, Wolfgang; DE
MERTES, Maria; DE
MISERA, Simon; DE
NASER, Werner; DE
WOLTERS, Brit; DE
HEINEMEYER, Thomas; DE
HEYSE, Gero; DE
Priority Data:
17183933.531.07.2017EP
Title (EN) THREE-DIMENSIONAL STRUCTURE-BASED HUMANIZATION METHOD
(FR) PROCÉDÉ D'HUMANISATION À BASE DE STRUCTURE TRIDIMENSIONNELLE
Abstract:
(EN) Herein is reported a method for the humanization of non-human antibodies using a structure-based scoring matrix. With the scoring matrix it is possible to determine (the requirement for and) the suitability of specific (back)mutations of amino acid residues at defined positions of a selected human germline sequence. The scoring matrix takes into account the topology, the three-dimensional structure and the interactions of the respective residue and change. Thereby the influence on antigen binding of a specific amino acid residue change can be determined.
(FR) La présente invention concerne un procédé d'humanisation d'anticorps non humains à l'aide d'une matrice de notation à base de structure. Avec la matrice de notation, il est possible de déterminer (l'exigence pour et) le caractère approprié de mutations (retour) spécifiques de résidus d'acides aminés à des positions définies d'une séquence de lignée germinale humaine sélectionnée. La matrice de notation prend en compte la topologie, la structure tridimensionnelle et les interactions du résidu et du changement respectifs. L'invention permet ainsi de déterminer l'influence sur la liaison à l'antigène d'un changement de résidu d'acide aminé spécifique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)