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1. (WO2019025029) METHOD FOR PREPARING BILE ACID COMPOUND VIA ENZYMATIC CATALYSIS
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Pub. No.: WO/2019/025029 International Application No.: PCT/EP2018/025208
Publication Date: 07.02.2019 International Filing Date: 01.08.2018
IPC:
C12P 33/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
33
Preparation of steroids
06
Hydroxylating
Applicants:
VIO CHEMICALS AG [CH/CH]; Dufourstrasse 107 8008 Zurich, CH
Inventors:
KOFTIS, Theocharis, V.; GR
NEOKOSMIDIS, Efstratios; GR
TERZIDIS, Michael; GR
ALEXANDRAKI, Elli; GR
GIOTI, Efthymia; GR
TRAKOSSAS, Sakellarios; GR
ANDREOU, Thanos; GR
VASTARDI, Elli; GR
DRIMAROPOULOU, Garyfallia; GR
Agent:
AIVALIOTIS, Apostolos; 44, Kifisias Avenue GR-15125 Maroussi, GR
Priority Data:
PCT/EP2017/02522803.08.2017EP
Title (EN) METHOD FOR PREPARING BILE ACID COMPOUND VIA ENZYMATIC CATALYSIS
(FR) PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ D'ACIDE BILIAIRE PAR CATALYSE ENZYMATIQUE
Abstract:
(EN) The present invention relates to the provision of an enzymatic method for the preparation of 1 β, 3α,7α,12α-tetrahydroxy bile acid (Formula I). The enzymatic method of the present invention is advantageous over conventional synthetic preparations, providing the selective insertion of a hydroxyl group without the need of employing protective groups or other synthetic maneuvers.
(FR) La présente invention concerne l'obtention d'un procédé enzymatique pour la préparation de l'acide 1β, 3α,7α,12α-tétrahydroxybiliaire (Formule I). Le procédé enzymatique selon la présente invention est avantageux par rapport aux préparations synthétiques classiques, fournissant l'insertion sélective d'un groupement hydroxyle sans avoir besoin d'employer des groupements protecteurs ou d'autres manœuvres synthétiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)