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1. (WO2019024924) AMINE COMPOUND FOR INHIBITING SSAO/VAP-1 AND USE THEREOF IN MEDICINE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/024924 International Application No.: PCT/CN2018/098563
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07C 211/29 (2006.01) ,C07C 217/54 (2006.01) ,C07C 211/26 (2006.01) ,A61K 31/135 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
26
of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
29
the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
54
having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
26
of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
广东东阳光药业有限公司 SUNSHINE LAKE PHARMA CO., LTD. [CN/CN]; 中国广东省东莞市 松山湖科技产业园区 Northern Industrial Area, Songshan Lake Dongguan, Guangdong 523000, CN
Inventors:
顾峥 GU, Zheng; CN
黎健豪 LI, Jianhao; CN
李峥 LI, Zheng; CN
王伟华 WANG, Weihua; CN
覃浩雄 QIN, Haoxiong; CN
崔云增 CUI, Yunzeng; CN
王绪礼 WANG, Xuli; CN
余淑娜 YU, Shuna; CN
张英俊 ZHANG, Yingjun; CN
Priority Data:
201710659419.104.08.2017CN
Title (EN) AMINE COMPOUND FOR INHIBITING SSAO/VAP-1 AND USE THEREOF IN MEDICINE
(FR) COMPOSÉ AMINE POUR INHIBER SSAO/VAP-1 ET SON UTILISATION EN MÉDECINE
(ZH) 抑制SSAO/VAP-1的胺类化合物及其在医药上的应用
Abstract:
(EN) The present invention relates to an amine compound for inhibiting semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1) inhibitors and use thereof in medicine, and further relates to a pharmaceutical composition comprising the amine compound. Said compound and pharmaceutical composition can be used for treating inflammation and/or inflammation related diseases, diabetes and/or diabetes related diseases, psychiatric disorders, ischemic diseases, vascular diseases, fibrosis or tissue transplant rejection.
(FR) La présente invention concerne un composé amine pour inhiber l'amine oxydase sensible au semicarbazide (SSAO) et/ou des inhibiteurs de la protéine 1 d'adhésion vasculaire (VAP-1) et son utilisation en médecine, l'invention concerne en outre une composition pharmaceutique comprenant le composé amine. Ledit composé et ladite composition pharmaceutique peuvent être utilisés pour traiter une inflammation et/ou des maladies associées à une inflammation, le diabète et/ou des maladies associées au diabète, des troubles psychiatriques, des maladies ischémiques, des maladies vasculaires, la fibrose ou le rejet de greffe de tissu.
(ZH) 一种用于抑制氨基脲敏感性氧化酶(SSAO)和/或血管黏附蛋白-1(VAP-1)抑制剂的胺类化合物及其在医药上的应用,进一步涉及含有该胺类化合物的药物组合物。所述的化合物及药物组合物可用于治疗炎症和/或炎症相关疾病、糖尿病和/或糖尿病相关疾病、精神病症、缺血性疾病、血管疾病、纤维化或组织移植排斥。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)