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1. (WO2019024920) METHODS FOR PREPARING BILE ACIDS
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Pub. No.: WO/2019/024920 International Application No.: PCT/CN2018/098535
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07J 9/00 (2006.01) ,C07J 1/00 (2006.01) ,C07J 13/00 (2006.01) ,C07J 75/00 (2006.01) ,A61K 31/56 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
9
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
1
Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
13
Normal steroids containing carbon, hydrogen, halogen, or oxygen, having a carbon-to-carbon double bond from or to position 17
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
75
Processes for the preparation of steroids, in general
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
LIU, Dejun [CN/CN]; CN (US)
QIAN, Yingzhe [CN/CN]; CN (US)
MEDYTOX INC. [KR/KR]; 78, Gangni 1-gil, Ochang-eup Cheongwon-gu, Cheongju-si Chungcheongbuk-do, 28126, KR
Inventors:
LIU, Dejun; CN
QIAN, Yingzhe; CN
LEE, Junho; KR
SONG, Yoonseok; KR
Agent:
ZHONGZI LAW OFFICE; 7F, New Era Building 26 Pinganli Xidajie, Xicheng District Beijing 100034, CN
Priority Data:
PCT/CN2017/09578403.08.2017CN
Title (EN) METHODS FOR PREPARING BILE ACIDS
(FR) PROCÉDÉS DE PRÉPARATION D'ACIDES BILIAIRES
Abstract:
(EN) The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, for example, as described for methods 1, 1A, 1B, 2, 3, 3A, and 4. The method can start with a plant derived steroid as a starting material, such as dehydroepiandrosterone (DHEA) or Acetyl-dehydroepiandrosterone (Ac-DHEA). Also provided are pharmaceutical or cosmetic compositions and uses thereof, which comprise one or more of cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, which is of high purity, for example, free of animal derived impurities.
(FR) La présente invention concerne des procédés de préparation d'acide cholique, d'acide désoxycholique, ou d'acide chénodésoxycholique, d'un ester de celui-ci, ou d'un sel acceptable sur le plan pharmaceutique ou cosmétique de celui-ci, et de nouveaux intermédiaires synthétiques utiles, par exemple, comme décrit pour les procédés 1, 1A, 1B, 2, 3, 3A, et 4. Le procédé peut démarrer avec un stéroïde dérivé d'une plante comme matériau de départ, tel que la déshydroépiandrostérone (DHEA) ou l'acétyl-déshydroépiandrostérone (Ac-DHEA). L'invention concerne également des compositions pharmaceutiques ou cosmétiques et leurs utilisations, qui comprennent un ou plusieurs parmi l'acide cholique, l'acide désoxycholique, ou l'acide chénodésoxycholique, un ester de celui-ci, ou un sel acceptable sur le plan pharmaceutique ou cosmétique de celui-ci, qui est de haute pureté, par exemple, exempt d'impuretés dérivées d'un animal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)