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1. (WO2019024911) B7H3 ANTIBODY-DRUG CONJUGATE AND MEDICAL USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/024911 International Application No.: PCT/CN2018/098480
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
A61K 39/395 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/00 (2006.01) ,A61K 47/68 (2017.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区昆仑山路7号 No.7 Kunlunshan Road, Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
上海恒瑞医药有限公司 SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN/CN]; 中国上海市 闵行区文井路279号 No.279 Wenjing Road, Minhang District Shanghai 200245, CN
Inventors:
顾津明 GU, Jinming; CN
叶鑫 YE, Xin; CN
杨柳青 YANG, Liuqing; CN
梁金栋 LIANG, Jindong; CN
蒋贵阳 JIANG, Guiyang; CN
陶维康 TAO, Weikang; CN
张连山 ZHANG, Lianshan; CN
应华 YING, Hua; CN
张玲 ZHANG, Ling; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层程伟(DavidW.CHENG) David W. CHENG Level 19, Tower E3, the Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201710660432.904.08.2017CN
Title (EN) B7H3 ANTIBODY-DRUG CONJUGATE AND MEDICAL USE THEREOF
(FR) CONJUGUÉ ANTICORPS ANTI-B7H3-MÉDICAMENT ET SON UTILISATION MÉDICALE
(ZH) B7H3抗体-药物偶联物及其医药用途
Abstract:
(EN) Provided are a B7H3 antibody-drug conjugate and medical use thereof. In particular, provided are a B7H3 antibody-cytotoxic drug conjugate or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the aforementioned conjugate or the pharmaceutically acceptable salt or solvate thereof, and use thereof in the preparation of a medicament for the treatment of a B7H3-mediated disease or condition, especially in the preparation of anticancer drugs.
(FR) L'invention concerne un conjugué anticorps anti-B7H3-médicament et son utilisation médicale. En particulier, l'invention concerne un conjugué anticorps anti-B7H3-médicament cytotoxique ou un sel ou solvate pharmaceutiquement acceptable de celui-ci, une composition pharmaceutique comprenant le conjugué précité ou le sel ou solvate pharmaceutiquement acceptable de celui-ci, et son utilisation dans la préparation d'un médicament pour le traitement d'une maladie ou d'une affection médiée par B7H3, notamment dans la préparation de médicaments anticancéreux.
(ZH) 一种B7H3抗体-药物偶联物及其医药用途。具体而言,B7H3抗体-细胞毒性药物偶联物或其药学上可接受的盐或溶剂化合物,以及包含前述偶联物或其药学上可接受的盐或溶剂化合物的药物组合物,以及其制备用于治疗B7H3介导的疾病或病症的药物中的用途;尤其在制备抗癌药物中的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)