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1. (WO2019024845) CRYSTAL FORM OF OREXIN RECEPTOR ANTAGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
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Pub. No.: WO/2019/024845 International Application No.: PCT/CN2018/097797
Publication Date: 07.02.2019 International Filing Date: 31.07.2018
IPC:
C07D 239/34 (2006.01) ,A61K 31/506 (2006.01) ,A61P 25/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
34
One oxygen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
20
Hypnotics; Sedatives
Applicants:
苏州科睿思制药有限公司 CRYSTAL PHARMACEUTICAL (SUZHOU) CO., LTD. [CN/CN]; 中国江苏省苏州市 工业园区星湖街218号生物纳米园B4-301赵林林 ZHAO, Linlin B4-301, Biobay, 218 Xinghu Street, Suzhou Industrial Park Suzhou, Jiangsu 215123, CN
Inventors:
陈敏华 CHEN, Minhua; CN
张炎锋 ZHANG, Yanfeng; CN
黄春香 HUANG, Chunxiang; CN
张晓宇 ZHANG, Xiaoyu; CN
Priority Data:
201710648135.201.08.2017CN
Title (EN) CRYSTAL FORM OF OREXIN RECEPTOR ANTAGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) FORME CRISTALLINE D'ANTAGONISTE DU RÉCEPTEUR DE L'OREXINE, PROCÉDÉ DE PRÉPARATION ASSOCIÉ ET UTILISATION CORRESPONDANTE
(ZH) 一种食欲素受体拮抗剂的晶型及其制备方法和用途
Abstract:
(EN) A crystal form of a compound Lemborexant, a preparation method therefor, a pharmaceutical composition comprising the crystal form, and use of the crystal form in the preparation of an orexin receptor antagonist and of a pharmaceutical formulation for treating insomnia and irregular sleep-wake rhythm disorder. The crystal form of the compound Lemborexant provided by the present invention has one or more improved properties with respect to the prior art, having great value for the optimization and development of this medicament in the future.
(FR) L'invention concerne une forme cristalline d'un composé, le Lemborexant, son procédé de préparation, une composition pharmaceutique comprenant la forme cristalline, et l'utilisation de la forme cristalline dans la préparation d'un antagoniste du récepteur de l'orexine et d'une formulation pharmaceutique pour le traitement de l'insomnie et d'un trouble du rythme du sommeil irrégulier. La nouvelle forme cristalline du composé, le Lemborexant, de la présente invention possède au moins une propriété améliorée par rapport à celles de l'état de la technique, possédant une grande valeur pour l'optimisation et la mise au point de ce médicament à l'avenir.
(ZH) 一种化合物Lemborexant的晶型及其制备方法,含有该晶型的药物组合物,以及该晶型在制备食欲素受体拮抗剂、治疗失眠症和不规则睡眠-觉醒节律障碍药物制剂中的用途。提供的化合物Lemborexant的晶型比现有技术具有一种或多种改进的特性,对未来该药物的优化和开发具有重要价值。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)