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1. (WO2019024758) APPLICATION OF GLYCOSIDE COMPOUND IN PREPARING DRUG FOR TREATING HEPATIC FIBROSIS
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Pub. No.: WO/2019/024758 International Application No.: PCT/CN2018/097201
Publication Date: 07.02.2019 International Filing Date: 26.07.2018
IPC:
A61K 31/7048 (2006.01) ,A61P 1/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7048
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants:
华中科技大学 HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN/CN]; 中国湖北省武汉市 洪山区珞喻路1037号 No. 1037, Luoyu Road, Hongshan District Wuhan, Hubei 430074, CN
Inventors:
张勇慧 ZHANG, Yonghui; CN
向明 XIANG, Ming; CN
刘婷婷 LIU, Tingting; CN
Agent:
武汉开元知识产权代理有限公司 WUHAN KAIYUAN INTELLECTUAL PROPERTY AGENT LTD.; 中国湖北省武汉市 江岸区香港路145号远洋大厦14层 14th Floor, Yuanyang Building No. 145, Xianggang Road, Jiang'an District Wuhan, Hubei 430015, CN
Priority Data:
201710652728.602.08.2017CN
Title (EN) APPLICATION OF GLYCOSIDE COMPOUND IN PREPARING DRUG FOR TREATING HEPATIC FIBROSIS
(FR) APPLICATION D'UN COMPOSÉ GLYCOSIDE DANS LA PRÉPARATION D'UN MÉDICAMENT POUR LE TRAITEMENT DE LA FIBROSE HÉPATIQUE
(ZH) 一种糖苷类化合物在制备用于治疗肝纤维化药物中的应用
Abstract:
(EN) The present invention relates to the technical field of medicine. Provided is a drug for treating hepatic fibrosis. According to the present invention, by evaluating the activity of a compound, i.e., kinsenoside, in treating hepatic fibrosis, it is found that the compound is able to effectively inhibit development of the hepatic fibrosis and produce, in vivo, the activity of reducing expression of fibrosis marker genes, improving liver functions, ameliorating oxidative stress injuries and reducing secretion of inflammatory factors, and can be used as a lead compound in development of a drug for treating the hepatic fibrosis.
(FR) La présente invention concerne le domaine technique de la médecine. L'invention concerne un médicament pour le traitement de la fibrose hépatique. Selon la présente invention, en évaluant l'activité d'un composé, c'est-à-dire le kinsénoside, dans le traitement de la fibrose hépatique, on constate que le composé est capable d'inhiber efficacement le développement de la fibrose hépatique et de produire in vivo, une activité de réduction de l'expression de gènes de marqueurs de la fibrose, une amélioration des fonctions hépatiques, une amélioration des lésions de stress oxydatif et une réduction de la sécrétion de facteurs inflammatoires, et qu'il peut être utilisé en tant que composé principal dans le développement d'un médicament pour le traitement de la fibrose hépatique.
(ZH) 本发明属于医药技术领域,提供了一种治疗肝纤维化的药物,本发明通过对化合物金线莲苷的治疗肝纤维化活性进行评价,发现该化合物能够有效阻止肝纤维化的发展,在体内产生一定的降低纤维化标志基因表达、改善肝功能和氧化应激损伤、降低炎性因子分泌等活性,可以作为治疗肝纤维化药物开发的先导化合物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)