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1. (WO2019024598) DNA PROBE LIBRARY FOR HYBRIDIZATION WITH MICRO-SATELLITE INSTABILITY RELATED MICRO-SATELLITE SITES, DETECTION METHOD AND KIT
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Pub. No.: WO/2019/024598 International Application No.: PCT/CN2018/090084
Publication Date: 07.02.2019 International Filing Date: 06.06.2018
IPC:
C12Q 1/68 (2018.01) ,C40B 40/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
06
Libraries containing nucleotides or polynucleotides, or derivatives thereof
Applicants:
南京世和基因生物技术有限公司 GENESEEQ TECHNOLOGY INC. [CN/CN]; 中国江苏省南京市 浦口区高新技术开发区新锦湖路3-1号中丹生态生命科学产业园B座18楼 Floor 18, Block B, Zhongdanyuan, No. 3-1 Xinjinhu Road, High-tech District Nanjing, Jiangsu 210032, CN
Inventors:
邵阳 SHAO, Yang; CN
蒋斯明 JIANG, Siming; CN
汪笑男 WANG, Xiaonan; CN
吴雪 WU, Xue; CN
常志力 CHANG, Zhili; CN
马骧原 MA, Xiangyuan; CN
张宪 ZHANG, Xian; CN
Agent:
南京汇恒知识产权代理事务所(普通合伙) NANJING HUIHENG INTELLECTUAL PROPERTY AGENCY OFFICE (GENERAL PARTNERSHIP); 中国江苏省南京市 国家经济开发区兴智路兴智科技园C栋412室 Room 412, Building C, Xingzhi Park, Xingzhi Road, National Economic Development Zone Nanjing, Jiangsu 210049, CN
Priority Data:
201710647677.801.08.2017CN
Title (EN) DNA PROBE LIBRARY FOR HYBRIDIZATION WITH MICRO-SATELLITE INSTABILITY RELATED MICRO-SATELLITE SITES, DETECTION METHOD AND KIT
(FR) BIBLIOTHÈQUE DE SONDES D'ADN POUR HYBRIDATION AVEC DES SITES DE MICRO-SATELLITES LIÉS À L'INSTABILITÉ DES MICRO-SATELLITES, PROCÉDÉ DE DÉTECTION ET KIT
(ZH) 一种用于与微卫星不稳定性相关微卫星位点进行杂交的DNA探针库、检测方法和试剂盒
Abstract:
(EN) A DNA probe library for hybridization with micro-satellite instability (MSI) detection related micro-satellite sites, comprising one or more DNA probes capable of hybridizing with the MSI state related microsatellite sites. In the DNA probes, the MSI related micro-satellite sites are shown in the following sequences: SEQ ID NOs. 1-66. In addition, provided is a method for enriching and detecting the MSI related micro-satellite sites by using the probe library. By combining the method with the next-generation sequencing technology (NGS), the sensitivity, accuracy and comprehensiveness of MSI detection can be greatly improved.
(FR) Une bibliothèque de sondes d'ADN, pour hybridation avec des sites de micro-satellites liés à la détection de l'instabilité des micro-satellites (MSI), comprend une ou plusieurs sondes d'ADN pouvant s'hybrider aux sites de microsatellites liés à l'état de MSI. Dans les sondes d'ADN, les sites micro-satellites liés à des MSI sont représentés dans les numéros de séquences suivantes : SEQ ID NO. 1-66. De plus, l'invention concerne un procédé d'enrichissement et de détection des sites de micro-satellites liés à des MSI au moyen de la bibliothèque de sondes. En combinant le procédé avec la technologie de séquençage de nouvelle génération (NGS), la sensibilité, la précision et l'intelligibilité de la détection de MSI peuvent être considérablement améliorées.
(ZH) 一种用于与微卫星不稳定性(MSI)检测相关的微卫星位点进行杂交的DNA探针库,所述DNA探针库包括一个或多个能够与MSI状态相关微卫星位点进行杂交的DNA探针。所述DNA探针中,MSI相关微卫星位点探针如以下序列所示:SEQ ID NO.1~66。此外,提供利用该探针库对MSI相关微卫星位点进行富集及检测的方法,采用此方法与下一代测序技术(NGS)相结合可以极大地提高MSI检测的敏感性,准确性与全面性。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)