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1. (WO2019024579) GENE MARKER FOR DETECTING LUNG CANCER, KIT AND LUNG CANCER DETECTION METHOD
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Pub. No.: WO/2019/024579 International Application No.: PCT/CN2018/088134
Publication Date: 07.02.2019 International Filing Date: 24.05.2018
IPC:
C12Q 1/68 (2018.01) ,G01N 33/00 (2006.01) ,C12N 5/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants:
上海易毕恩生物技术有限公司 SHANGHAI EPICAN BIOTECHNOLOGY CO., LTD. [CN/CN]; 中国上海市 青浦区华浦路500号2号厂房 No. 2 Building No. 500 Huapu Road, Qingpu District Shanghai 201700, CN
上海易毕恩基因科技有限公司 SHANGHAI EPICAN GENETECH CO., LTD. [CN/CN]; 中国中国上海市 中国(上海)自由贸易试验区爱迪生路328号201-2室 Room 201-2 328 Aidisheng Road China (Shanghai) Pilot Free Trade Zone Shanghai 201210, CN
Inventors:
陆星宇 LU, Xingyu; CN
宋艳群 SONG, Yanqun; CN
彭莱 PENG, Lai; CN
张子谋 ZHANG, Zimou; CN
Agent:
上海精晟知识产权代理有限公司 SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO., LTD.; 中国上海市 杨浦区控江路1555号A座1105室 Room 1105, Building A No. 1555 Kong Jiang Road, Yangpu District Shanghai 200092, CN
Priority Data:
201710662853.504.08.2017CN
Title (EN) GENE MARKER FOR DETECTING LUNG CANCER, KIT AND LUNG CANCER DETECTION METHOD
(FR) MARQUEUR DE GÈNE PERMETTANT DE DÉTECTER UN CANCER DU POUMON, KIT ET PROCÉDÉ DE DÉTECTION DE CANCER DU POUMON
(ZH) 用于检测肺癌的基因标志物、试剂盒及肺癌检测方法
Abstract:
(EN) The present invention provides a gene marker for detecting a lung cancer, a kit, and a lung cancer detection method. According to the present invention, the content of 5-hydroxymethylcytosine in one or more genes of RUNX1 transposition partner gene 1, F-Box and leucine-rich repeat protein 7, RNcA binding motif single-chain interacting protein 3, cadherin 11, erythrocyte membrane protein band 4.1 protein 4A, basonuclin 2, Tolloid protein 1, sulfatase 1, integrin subunit α8, and R-spinal protein 3 is detected by means of high-throughput sequencing, so as to determine whether the lung cancer exists or not.
(FR) La présente invention concerne un marqueur de gène permettant de détecter un cancer du poumon, un kit et un procédé de détection du cancer du poumon. Selon la présente invention, la teneur en 5-hydroxyméthylcytosine dans un ou plusieurs gènes du gène 1 partenaire de transposition RUNX1, de la boîte F et de la protéine 7 de répétition riche en leucine, de la protéine 3 d'interaction à chaîne unique à motif de liaison RNcA, de la cadhérine 11, de la protéine 4A de la bande 4.1 des protéines membranaires érythrocytaires, de la nucléoprotéine basophile 2, de la protéine de tolloïde 1, de la sulfatase 1, de la sous-unité α8 de l'intégrine, et de la protéine R-spinale 3 est détectée au moyen d'un séquençage à haut débit, de façon à déterminer si le cancer du poumon existe ou non.
(ZH) 本发明提供了用于检测肺癌的基因标志物、试剂盒及肺癌检测方法。通过高通量测序检测RUNX1转位伴侣基因1、F-Box和富含亮氨酸重复序列的蛋白质7、RNcA结合基序单链相互作用蛋白3、钙粘着蛋白11、红细胞膜蛋白谱带4.1样蛋白4A、碱核蛋白2、Tolloid样蛋白1、硫酸酯酶1、整合素亚基α8和R-脊椎蛋白3中一个或两个以上基因中5-羟甲基胞嘧啶的含量,从而判定肺癌是否存在。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)