Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019024578) GENE MARKER FOR DETECTING BENIGN AND MALIGNANT LIVER TUMORS, KIT AND DETECTION METHOD
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/024578 International Application No.: PCT/CN2018/088132
Publication Date: 07.02.2019 International Filing Date: 24.05.2018
IPC:
C12Q 1/68 (2018.01) ,G01N 33/00 (2006.01) ,C12N 5/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants:
上海易毕恩生物技术有限公司 SHANGHAI EPICAN BIOTECHNOLOGY CO., LTD. [CN/CN]; 中国上海市 青浦区华浦路500号2号厂房 No. 2 Building, No. 500 Huapu Road, Qingpu District Shanghai 201700, CN
上海易毕恩基因科技有限公司 SHANGHAI EPICAN GENETECH CO., LTD. [CN/CN]; 中国上海市 中国(上海)自由贸易试验区爱迪生路328号201-2室 Room 201-2 328 Aidisheng Road, China (Shanghai) Pilot Free Trade Zone Shanghai 201210, CN
Inventors:
陆星宇 LU, Xingyu; CN
宋艳群 SONG, Yanqun; CN
彭莱 PENG, Lai; CN
张子谋 ZHANG, Zimou; CN
Agent:
上海精晟知识产权代理有限公司 SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO., LTD.; 中国上海市 杨浦区控江路1555号A座1105室 Room 1105, Building A No.1555 Kong Jiang Road, Yangpu District Shanghai 200092, CN
Priority Data:
201710662852.004.08.2017CN
Title (EN) GENE MARKER FOR DETECTING BENIGN AND MALIGNANT LIVER TUMORS, KIT AND DETECTION METHOD
(FR) MARQUEUR DE GÈNE POUR DÉTECTER DES TUMEURS BÉNIGNES ET MALIGNES DU FOIE, KIT ET PROCÉDÉ DE DÉTECTION
(ZH) 用于检测肝肿瘤良恶性的基因标志物、试剂盒及检测方法
Abstract:
(EN) The present invention provides a gene marker for detecting benign and malignant liver tumors, a kit, and a detection method. According to the present invention, the content of 5-hydroxymethylcytosine in one or more marker genes of FAT atypical cadherin 1, estrogen-related receptor γ, sex-determining gene y pseudoautosomal region and family member 9, ciliate complex subunit 1, No. 1 chromosome open reading frame 125 antibody, RELN, transferrin, TNF TNFRSF, pancreas and duodenum homologous frame 1, and α-acidoglycoprotein 2 is detected by means of high-throughput sequencing, so as to determine the benign and malignant liver tumors.
(FR) La présente invention concerne un marqueur de gène pour détecter des tumeurs bénignes et malignes du foie, un kit, et un procédé de détection. Selon la présente invention, la teneur de la 5-hydroxyméthylcytosine dans un ou plusieurs marqueurs de gènes de la cadhérine 1 atypique FAT, du récepteur γ lié aux œstrogènes, de la région pseudo-autosomique du gène y de détermination du sexe et l'élément de la famille 9, la sous-unité du complexe cilié 1, l'anticorps du cadre de lecture ouvert 125 du chromosome 1, du RELN, de la transferrine, du TNF TNFRSF, du cadre homologue du pancréas et du duodénum 1, et d'une α-acidoglycoprotéine 2 est détectée à l'aide d'un séquençage à haut débit, afin d'identifier les tumeurs bénignes et malignes du foie.
(ZH) 本发明提供了用于检测肝肿瘤良恶性的基因标志物、试剂盒及检测方法。通过高通量测序检测FAT非典型钙粘蛋白1、雌激素相关受体γ、性别决定基因y染色体区域盒家族成员9、纤毛状络合物子单元1、1号染色体开放阅读框125抗体、络丝蛋白、转铁蛋白、TNF受体超家族成员、胰腺和十二指肠同圆框1、α-酸性糖蛋白2中一个或两个以上标志基因中5-羟甲基胞嘧啶的含量,从而判定肝肿瘤良恶性
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)